| http://purl.uniprot.org/citations/16199866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16199866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16199866 | http://www.w3.org/2000/01/rdf-schema#comment | "The activity of GATA factors is regulated, in part, at the level of protein-protein interactions. LIM domain proteins, first defined by the zinc finger motifs found in the Lin11, Isl-1, and Mec-3 proteins, act as coactivators of GATA function in both hematopoietic and cardiovascular tissues. We have identified a novel GATA-LIM interaction between GATA6 and LMCD1/dyxin. The LIM domains and cysteine-rich domains in LMCD1/dyxin and the carboxy-terminal zinc finger of GATA6 mediate this interaction. Expression of LMCD1/dyxin is remarkably similar to that of GATA6, with high-level expression observed in distal airway epithelium of the lung, vascular smooth muscle, and myocardium. In contrast to other GATA-LIM protein interactions, LMCD1/dyxin represses GATA6 activation of both lung and cardiac tissue-specific promoters. Electrophoretic mobility shift and chromatin immunoprecipitation assays show that LMCD1/dyxin represses GATA6 function by inhibiting GATA6 DNA binding. These data reveal an interaction between GATA6 and LMCD1/dyxin and demonstrate a novel mechanism through which LIM proteins can assert their role as transcriptional cofactors of GATA proteins."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.20.8864-8873.2005"xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.20.8864-8873.2005"xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/author | "Lu M.M."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/author | "Lu M.M."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/author | "Morrisey E.E."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/author | "Morrisey E.E."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/author | "Rath N."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/author | "Rath N."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/pages | "8864-8873"xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/pages | "8864-8873"xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/title | "LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/title | "LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding."xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16199866 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16199866 |
| http://purl.uniprot.org/citations/16199866 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16199866 |