| http://purl.uniprot.org/citations/16200070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16200070 | http://www.w3.org/2000/01/rdf-schema#comment | "CD4(+) T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (T(H)1) or T(H)2 lineages and instead favor the idea of a distinct effector lineage we call 'T(H)-17'. The development of T(H)-17 cells from naive precursor cells was potently inhibited by interferon-gamma (IFN-gamma) and IL-4, whereas committed T(H)-17 cells were resistant to suppression by T(H)1 or T(H)2 cytokines. In the absence of IFN-gamma and IL-4, IL-23 induced naive precursor cells to differentiate into T(H)-17 cells independently of the transcription factors STAT1, T-bet, STAT4 and STAT6. These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of pathogenic T(H)-17 effector cells that can exacerbate autoimmunity."xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1254"xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/author | "Hatton R.D."xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/author | "Murphy T.L."xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/author | "Weaver C.T."xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/author | "Turner H."xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/author | "Harrington L.E."xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/author | "Mangan P.R."xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/pages | "1123-1132"xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/title | "Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages."xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/16200070 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16200070 |
| http://purl.uniprot.org/citations/16200070 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16200070 |
| http://purl.uniprot.org/uniprot/#_A0A087WSP5-mappedCitation-16200070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16200070 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ5-mappedCitation-16200070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16200070 |
| http://purl.uniprot.org/uniprot/#_A0A087WRI1-mappedCitation-16200070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16200070 |
| http://purl.uniprot.org/uniprot/#_P15261-mappedCitation-16200070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16200070 |
| http://purl.uniprot.org/uniprot/#_P52633-mappedCitation-16200070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16200070 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C347-mappedCitation-16200070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16200070 |
| http://purl.uniprot.org/uniprot/#_A0A7R8GUQ3-mappedCitation-16200070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16200070 |
| http://purl.uniprot.org/uniprot/#_A3RL32-mappedCitation-16200070 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16200070 |