| http://purl.uniprot.org/citations/16203866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16203866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16203866 | http://www.w3.org/2000/01/rdf-schema#comment | "T cell immunoglobulin-domain and mucin-domain (TIM) proteins constitute a receptor family that was identified first on kidney and liver cells; recently it was also shown to be expressed on T cells. TIM-1 and -3 receptors denote different subsets of T cells and have distinct regulatory effects on T cell function. Ferritin is a spherical protein complex that is formed by 24 subunits of H- and L-ferritin. Ferritin stores iron atoms intracellularly, but it also circulates. H-ferritin, but not L-ferritin, shows saturable binding to subsets of human T and B cells, and its expression is increased in response to inflammation. We demonstrate that mouse TIM-2 is expressed on all splenic B cells, with increased levels on germinal center B cells. TIM-2 also is expressed in the liver, especially in bile duct epithelial cells, and in renal tubule cells. We further demonstrate that TIM-2 is a receptor for H-ferritin, but not for L-ferritin, and expression of TIM-2 permits the cellular uptake of H-ferritin into endosomes. This is the first identification of a receptor for ferritin and reveals a new role for TIM-2."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20042433"xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20042433"xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Chen C.Y."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Chen C.Y."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Cyster J.G."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Cyster J.G."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Li L."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Brodsky F.M."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Brodsky F.M."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Chen T.T."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Chen T.T."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Chung D.H."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Chung D.H."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Nakamura M.C."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Nakamura M.C."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Niemi E.C."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Niemi E.C."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Daws M.R."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Daws M.R."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Seaman W.E."xsd:string |
| http://purl.uniprot.org/citations/16203866 | http://purl.uniprot.org/core/author | "Seaman W.E."xsd:string |