DESCRIBE <http://purl.uniprot.org/citations/16205917>

Subject	Predicate	Object
http://purl.uniprot.org/citations/16205917	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16205917	http://www.w3.org/2000/01/rdf-schema#comment	" Rationale In humans, social stress over long and short term can increase alcohol consumption, but the mechanisms involved are not understood. Objectives This study was conducted to examine the effects of social defeat, using the resident/intruder paradigm, on the alcohol preference of "low alcohol drinking" individuals in a colony of C57BL/10 strain mice and the effects of two anxiolytic drugs. Methods Alcohol preference, in a two-bottle choice (8% v/v alcohol or water), was measured, in separate experiments, after either a single experience of social defeat by a resident male mouse, five consecutive daily defeat experiences or one experience per week for 4 weeks. Comparison was made with effects of repeated social defeat on the preference for dilute sucrose. In addition, the actions of the CCKB receptor antagonist, CAM1028, and of diazepam were examined on the effects of repeated defeat experiences. Results Five consecutive daily defeat experiences had a slow onset effect in increasing alcohol preference and consumption, compared with five daily exposures to a novel environment. A single defeat, or one defeat per week, did not significantly alter alcohol preference or intake. There were no effects of five daily defeat experiences on sucrose preference or consumption. The effect of repeated defeats on alcohol preference was significantly decreased by administration of the CCKB receptor antagonist, CAM1028, prior to each experience, but not by corresponding administration of diazepam. Conclusion The results show that social stress increases alcohol intake in low alcohol preference C57BL/10 mice and suggest that CCK transmission may be involved in this effect."xsd:string
http://purl.uniprot.org/citations/16205917	http://purl.org/dc/terms/identifier	"doi:10.1007/s00213-005-0165-6"xsd:string
http://purl.uniprot.org/citations/16205917	http://purl.uniprot.org/core/author	"Brooks S.P."xsd:string
http://purl.uniprot.org/citations/16205917	http://purl.uniprot.org/core/author	"Cole J."xsd:string
http://purl.uniprot.org/citations/16205917	http://purl.uniprot.org/core/author	"Little H.J."xsd:string
http://purl.uniprot.org/citations/16205917	http://purl.uniprot.org/core/author	"Croft A.P."xsd:string
http://purl.uniprot.org/citations/16205917	http://purl.uniprot.org/core/date	"2005"xsd:gYear
http://purl.uniprot.org/citations/16205917	http://purl.uniprot.org/core/name	"Psychopharmacology (Berl)"xsd:string
http://purl.uniprot.org/citations/16205917	http://purl.uniprot.org/core/pages	"163-170"xsd:string
http://purl.uniprot.org/citations/16205917	http://purl.uniprot.org/core/title	"Social defeat increases alcohol preference of C57BL/10 strain mice; effect prevented by a CCKB antagonist."xsd:string
http://purl.uniprot.org/citations/16205917	http://purl.uniprot.org/core/volume	"183"xsd:string
http://purl.uniprot.org/citations/16205917	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/16205917
http://purl.uniprot.org/citations/16205917	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/16205917
http://purl.uniprot.org/uniprot/#_P56481-mappedCitation-16205917	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16205917
http://purl.uniprot.org/uniprot/#_Q3ZB46-mappedCitation-16205917	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16205917
http://purl.uniprot.org/uniprot/#_Q3ZB53-mappedCitation-16205917	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16205917
http://purl.uniprot.org/uniprot/#_Q8BYG7-mappedCitation-16205917	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16205917
http://purl.uniprot.org/uniprot/#_Q8BKF6-mappedCitation-16205917	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/16205917
http://purl.uniprot.org/uniprot/Q3ZB53	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16205917
http://purl.uniprot.org/uniprot/Q8BYG7	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16205917
http://purl.uniprot.org/uniprot/P56481	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16205917
http://purl.uniprot.org/uniprot/Q3ZB46	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16205917
http://purl.uniprot.org/uniprot/Q8BKF6	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/16205917