| http://purl.uniprot.org/citations/16208432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16208432 | http://www.w3.org/2000/01/rdf-schema#comment | "Mandibular condylar cartilage acts as both articular and growth plate cartilage during growth, and then becomes articular cartilage after growth is complete. Cartilaginous extracellular matrix is remodeled continuously via a combination of production, degradation by matrix metalloproteinases (MMPs), and inhibition of MMP activity by tissue inhibitors of metalloproteinases (TIMPs). This study attempted to clarify the age-related changes in the mRNA expression patterns of MMP-2, MMP-9, TIMP-1, TIMP-2, and TIMP-3 in mandibular condylar cartilage in comparison to tibial growth plate and articular cartilage using an in situ hybridization method in growing and adult rats. MMP-2 and MMP-9 were expressed in a wide range of condylar cartilage cells during growth, and their expression domains became limited to mature chondrocytes in adults. The patterns of TIMP-1 and TIMP-2 expression were similar to those of MMP-2 and MMP-9 during growth, and were maintained until adulthood. TIMP-3 was localized to hypertrophic chondrocytes throughout the growth stage. Therefore, we concluded that TIMP-1 and TIMP-2 were general inhibitors of MMP-2 and MMP-9 in condylar cartilage, while TIMP-3 regulates the collagenolytic degradation of the hypertrophic cartilage matrix."xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10735-005-9007-4"xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://purl.uniprot.org/core/author | "Bae J.W."xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://purl.uniprot.org/core/author | "Takahashi I."xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://purl.uniprot.org/core/author | "Mitani H."xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://purl.uniprot.org/core/author | "Onodera K."xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://purl.uniprot.org/core/author | "Sasano Y."xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://purl.uniprot.org/core/author | "Mitani H.'"xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16208432 | http://purl.uniprot.org/core/name | "J Mol Histol"xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://purl.uniprot.org/core/pages | "355-366"xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://purl.uniprot.org/core/title | "Age-related changes in the expression of gelatinase and tissue inhibitor of metalloproteinase genes in mandibular condylar, growth plate, and articular cartilage in rats."xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://purl.uniprot.org/core/volume | "36"xsd:string |
| http://purl.uniprot.org/citations/16208432 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16208432 |
| http://purl.uniprot.org/citations/16208432 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16208432 |
| http://purl.uniprot.org/uniprot/P30120#attribution-94833B46FCFE921C2DCDB3DFAA6E174C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16208432 |
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| http://purl.uniprot.org/uniprot/#_A0A8I6A3D8-mappedCitation-16208432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16208432 |
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| http://purl.uniprot.org/uniprot/#_A0A8A1UDE0-mappedCitation-16208432 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16208432 |
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