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http://purl.uniprot.org/citations/16210019http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16210019http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the immunocytochemical expression and presence of mRNA transcripts for basic fibroblast growth factor (bFGF) and its four receptors (FGFR-1, -2, -3, and -4) in ovaries from human adults and fetuses.

Design

Immunocytochemical and reverse transcription polymerase chain reaction (RT-PCR) study.

Setting

Major tertiary care and referral academic centers.

Patient(s)

Nine women and girls undergoing laparoscopic ovarian biopsy and 26 women undergoing second- and third-trimester pregnancy terminations.

Intervention(s)

None.

Main outcome measure(s)

Microscopic morphometric analysis, immunocytochemistry for bFGF and its receptors, and RT-PCR analyses.

Result(s)

The proteins for bFGF, FGFR-2, FGFR-3, and FGFR-4 were identified in oocytes of all follicular classes. Immunocytochemical expression of bFGF and its receptors was detected in granulosa cells of follicles from adolescents/women but not from fetuses. There was no immunocytochemical expression of FGFR-1. Transcripts of bFGF and its four receptors were identified by RT-PCR in all samples.

Conclusion(s)

The expression of bFGF and its receptors in human ovaries suggests that bFGF might have a role in early folliculogenesis."xsd:string
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http://purl.uniprot.org/citations/16210019http://purl.uniprot.org/core/author"Jin S."xsd:string
http://purl.uniprot.org/citations/16210019http://purl.uniprot.org/core/author"Kessler-Icekson G."xsd:string
http://purl.uniprot.org/citations/16210019http://purl.uniprot.org/core/author"Abir R."xsd:string
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http://purl.uniprot.org/citations/16210019http://purl.uniprot.org/core/author"Feldberg D."xsd:string
http://purl.uniprot.org/citations/16210019http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16210019http://purl.uniprot.org/core/name"Fertil Steril 84 Suppl"xsd:string
http://purl.uniprot.org/citations/16210019http://purl.uniprot.org/core/pages"1257-1268"xsd:string
http://purl.uniprot.org/citations/16210019http://purl.uniprot.org/core/title"Expression of basic fibroblast growth factor and its receptors in human ovarian follicles from adults and fetuses."xsd:string
http://purl.uniprot.org/citations/16210019http://purl.uniprot.org/core/volume"2"xsd:string
http://purl.uniprot.org/citations/16210019http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16210019
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