| http://purl.uniprot.org/citations/16210606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16210606 | http://www.w3.org/2000/01/rdf-schema#comment | "To complete their maturation and to participate in the humoral immune response, immature B cells that leave the bone marrow are targeted to specific areas in the spleen, where they differentiate into mature cells. Previously, we showed that immature B cells actively down-regulate their integrin-mediated migration to lymph nodes or sites of inflammation, enabling their targeting to the spleen to allow their final maturation. This inhibition is mediated by IFN-gamma, which is transcribed and secreted at low levels by these immature B cells and is down-regulated at the mature stage. The activating MHC class I receptor, Ly49D, which is expressed at high levels on immature B cells, stimulates this IFN-gamma secretion. In this study we show that B cells coexpress the inhibitory MHC class I receptor, Ly49G2. In addition, we demonstrate a tight regulation in the expression of the Ly49 family members on B cells that depends on their cell surface levels. High levels of Ly49G2 have a dominant inhibitory effect on Ly49D expressed at low levels on immature bone marrow and mature B cells, resulting in inhibition of IFN-gamma secretion. However, low levels of the inhibitory receptor, Ly49G2, coexpressed with high levels of the activating receptor, Ly49D, on the immigrating immature B cells enable the secretion of specific low levels of IFN-gamma. This expression pattern insures the inhibitory control of peripheral immature B cell to prevent premature encounter with an Ag while enabling entry to the lymph nodes during the mature stage."xsd:string |
| http://purl.uniprot.org/citations/16210606 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.175.8.5034"xsd:string |
| http://purl.uniprot.org/citations/16210606 | http://purl.uniprot.org/core/author | "Shachar I."xsd:string |
| http://purl.uniprot.org/citations/16210606 | http://purl.uniprot.org/core/author | "Becker-Herman S."xsd:string |
| http://purl.uniprot.org/citations/16210606 | http://purl.uniprot.org/core/author | "Hart G."xsd:string |
| http://purl.uniprot.org/citations/16210606 | http://purl.uniprot.org/core/author | "Flaishon L."xsd:string |
| http://purl.uniprot.org/citations/16210606 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16210606 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16210606 | http://purl.uniprot.org/core/pages | "5034-5042"xsd:string |
| http://purl.uniprot.org/citations/16210606 | http://purl.uniprot.org/core/title | "Tight regulation of IFN-gamma transcription and secretion in immature and mature B cells by the inhibitory MHC class I receptor, Ly49G2."xsd:string |
| http://purl.uniprot.org/citations/16210606 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/16210606 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16210606 |
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