| http://purl.uniprot.org/citations/16210630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16210630 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16210630 | http://www.w3.org/2000/01/rdf-schema#comment | "The gastrointestinal tract is populated by a multitude of specialized immune cells endowed with receptors for classical (class Ia) and nonclassical (class Ib) MHC proteins. To identify class I products that engage these receptors and impact immunity/tolerance, we studied gut-transcribed class Ib loci and their polymorphism in inbred, outbred, and wild-derived mice. Intestinal tissues enriched in epithelial cells contained abundant transcripts of ubiquitously expressed and preferentially gut-restricted Q and T class I loci. The latter category included the "blastocyst Mhc" gene, H2-Bl, and its putative paralog, Tw5. Expression of H2-Bl was previously detected only at the maternal/fetal interface, where it was proposed to induce immune tolerance via interactions with CD94/NKG2A receptors. Analysis of coding region polymorphism performed here revealed two major alleles of H2-Bl with conserved residues at positions critical for class I protein folding and peptide binding. Both divergent alleles are maintained in outbred and wild mice under selection for fecundity and pathogen resistance. Surprisingly, we found that alternative splicing of H2-Bl mRNA in gut tissues is prevalent and allele-specific. It leads to strain-dependent expression of diverse repertoires of canonical and noncanonical transcripts that may give rise to distinct ligands for intestinal NK cell, T cell, and/or intraepithelial lymphocyte receptors."xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.175.8.5248"xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/author | "Guidry P.A."xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/author | "Guidry P.A."xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/author | "Stroynowski I."xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/author | "Stroynowski I."xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/pages | "5248-5259"xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/pages | "5248-5259"xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/title | "The murine family of gut-restricted class Ib MHC includes alternatively spliced isoforms of the proposed HLA-G homolog, "blastocyst MHC"."xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/title | "The murine family of gut-restricted class Ib MHC includes alternatively spliced isoforms of the proposed HLA-G homolog, "blastocyst MHC"."xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/16210630 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16210630 |
| http://purl.uniprot.org/citations/16210630 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16210630 |
| http://purl.uniprot.org/citations/16210630 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16210630 |
| http://purl.uniprot.org/citations/16210630 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16210630 |
| http://purl.uniprot.org/uniprot/Q4VCN9 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16210630 |
| http://purl.uniprot.org/uniprot/Q4VCN1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16210630 |
| http://purl.uniprot.org/uniprot/Q4VCM4 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16210630 |