| http://purl.uniprot.org/citations/16213368 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16213368 | http://www.w3.org/2000/01/rdf-schema#comment | "TEL/AML1 (also known as ETV6/RUNX1) rearrangement is the most frequent genetic change in childhood B-acute lymphoblastic leukemia (ALL) and is associated with a favorable prognosis. Its presence in adult ALL, however, has been questionable, and any association between TEL/AML1 rearrangement and clinical prognosis is unknown. To reveal the presence and incidence of the TEL/AML1 rearrangement in adult ALL, we applied fluorescence in situ hybridization (FISH). We conducted extra-signal, dual-color fluorescence in situ hybridization (ES-FISH) for TEL/AML1 rearrangement on bone marrow cells from 74 adult ALL patients and analyzed the survival time. We demonstrated the TEL/AML1 rearrangement in 2 patients (2.7%) among 74 patients with ALL. Of 74 adult ALL patients, 3 (4.0%) showed deletion of the TEL gene without TEL/AML1 rearrangement. The mean survival time of patients with TEL/AML1+ALL and patients with cryptic TEL deletion was 33 and 5 months, respectively, whereas the mean survival time of 53 TEL/AML1-ALL patients was 16.7 months. TEL/AML1 rearrangement is not unique in childhood ALL, and cryptic TEL deletion without TEL/AML1 rearrangement was more frequent than the TEL/AML1 rearrangement in adult ALL. We recommend TEL/AML1 FISH in adult ALL patients because conventional cytogenetic studies so far have yielded uninformative results."xsd:string |
| http://purl.uniprot.org/citations/16213368 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cancergencyto.2005.02.020"xsd:string |
| http://purl.uniprot.org/citations/16213368 | http://purl.uniprot.org/core/author | "Lee D.S."xsd:string |
| http://purl.uniprot.org/citations/16213368 | http://purl.uniprot.org/core/author | "Lee J.H."xsd:string |
| http://purl.uniprot.org/citations/16213368 | http://purl.uniprot.org/core/author | "Lee C.K."xsd:string |
| http://purl.uniprot.org/citations/16213368 | http://purl.uniprot.org/core/author | "Kim Y.R."xsd:string |
| http://purl.uniprot.org/citations/16213368 | http://purl.uniprot.org/core/author | "Cho H.K."xsd:string |
| http://purl.uniprot.org/citations/16213368 | http://purl.uniprot.org/core/author | "Cho H.I."xsd:string |
| http://purl.uniprot.org/citations/16213368 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16213368 | http://purl.uniprot.org/core/name | "Cancer Genet Cytogenet"xsd:string |
| http://purl.uniprot.org/citations/16213368 | http://purl.uniprot.org/core/pages | "176-178"xsd:string |
| http://purl.uniprot.org/citations/16213368 | http://purl.uniprot.org/core/title | "The presence of TEL/AML1 rearrangement and cryptic deletion of the TEL gene in adult acute lymphoblastic leukemia (ALL)."xsd:string |
| http://purl.uniprot.org/citations/16213368 | http://purl.uniprot.org/core/volume | "162"xsd:string |
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