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http://purl.uniprot.org/citations/16215946http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16215946http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To detect the expression of the fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia(ALL) and its conformity to WHO classification.

Methods

Sixty-two children with ALL were investigated. The expression of fusion genes was determined by multiplex reverse transcription-polymerase chain reaction (RT-PCR), karyotyping (R band) and immunophenotyping (by flow cytometry) were also performed.

Results

Of the 62 patients, 23(37.1%) were found to carry 13 different fusion genes. The patients with immunophenotype of Pre-B-ALL were found to carry: TEL/AML1(3 cases); E2A/PBX1, E2A/HLF, TLS/ERG, MLL/AF4, MLL/AF9, MLL/AF10, MLL/AFX-MLL/AF6-MLL/ELL, MLL/AF6-MLL/ELL, dupMLL (one case for each); and HOX11 (6 cases). The patients with immunophenotype of Pre-T-ALL were found to carry: TAL1D (4 cases, one is also found to have HOX11 expression); and HOX11 (2 cases). The multiplex RT-PCR in combination with chromosome analysis revealed genetic abnormalities in 69.4%(43/62) of childhood ALL.

Conclusion

Multiplex RT-PCR combined with chromosome analysis and immunophenotyping can provide reliable and helpful information for the diagnosis, therapy evaluation and prognosis prediction in childhood ALL, which may also serve as a basis on which to implement the criteria of WHO classification."xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/author"He J."xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/author"Huang Y.P."xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/author"Li J.Q."xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/author"He Y.X."xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/author"He H.L."xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/author"Zhu L.L."xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/author"Chen Z.X."xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/author"Xue Y.Q."xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/author"Chai Y.H."xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/name"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/pages"551-553"xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/title"[Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia]."xsd:string
http://purl.uniprot.org/citations/16215946http://purl.uniprot.org/core/volume"22"xsd:string
http://purl.uniprot.org/citations/16215946http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16215946
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