| http://purl.uniprot.org/citations/16219388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16219388 | http://www.w3.org/2000/01/rdf-schema#comment | "Functional kainate receptors are expressed in the spinal cord substantia gelatinosa region, and their activation contributes to bi-directional regulation of excitatory synaptic transmission at primary afferent synapses with spinal cord substantia gelatinosa neurons. However, no study has reported a role(s) for kainate receptor subtypes in long-term synaptic plasticity phenomena in this region. Using gene-targeted mice lacking glutamate receptor 5 (GLU(K5)) or GLU(K6) subunit, we here show that GLU(K6) subunit, but not GLU(K5) subunit, is involved in the induction of long-term potentiation of excitatory postsynaptic potentials, evoked by two different protocols: (1) high-frequency primary afferent stimulation (100 Hz, 3 s) and (2) low-frequency spike-timing stimulation (1 Hz, 200 pulses). In addition, GLU(K6) subunit plays an important role in the expression of kainate-induced Ca2+ transients in the substantia gelatinosa. On the other hand, genetic deletion of GLU(K5) or GLU(K6) subunit does not prevent the induction of long-term depression. These results indicate that unique expression of kainate receptors subunits is important in regulating spinal synaptic plasticity and thereby processing of sensory information, including pain."xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molbrainres.2005.09.004"xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://purl.uniprot.org/core/author | "Park Y.K."xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://purl.uniprot.org/core/author | "Gerber G."xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://purl.uniprot.org/core/author | "Randic M."xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://purl.uniprot.org/core/author | "Youn D.H."xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://purl.uniprot.org/core/author | "Galik J."xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://purl.uniprot.org/core/author | "Voitenko N."xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16219388 | http://purl.uniprot.org/core/name | "Brain Res Mol Brain Res"xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://purl.uniprot.org/core/pages | "9-18"xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://purl.uniprot.org/core/title | "Altered long-term synaptic plasticity and kainate-induced Ca2+ transients in the substantia gelatinosa neurons in GLU(K6)-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://purl.uniprot.org/core/volume | "142"xsd:string |
| http://purl.uniprot.org/citations/16219388 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16219388 |
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