| http://purl.uniprot.org/citations/16219661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16219661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16219661 | http://www.w3.org/2000/01/rdf-schema#comment | "Calcium-activated chloride currents (I(Cl(Ca))) can be recorded in almost all cells, but the molecular identity of the channels underlying this Cl-conductance is still incompletely understood. Here, I report that tweety, a gene located in Drosophila flightless, possesses five or six transmembrane segments, and that a human homologue of tweety (hTTYH3) is a novel large-conductance Ca2+-activated Cl-channel, while the related gene, hTTYH1, is a swelling-activated Cl-current. hTTYH3 is expressed in excitable tissues, including the heart, brain and skeletal muscle, whereas hTTYH1 is expressed mainly in the brain. Expression of hTTYH3 in CHO cells generated a unique Cl-current activated by an increase in the intracellular Ca2+ concentration. The hTTYH3-induced Cl-current had a linear current-voltage (I-V) relationship, a large single-channel conductance (260 pS) and the anion permeability sequence I- > Br-> Cl-. Like native Ca2+-activated Cl-channels, the hTTYH3 channel showed complex gating kinetics and voltage-dependent inactivation, and was dependent on micromolar intracellular Ca2+ concentration. Expression in CHO cells of an hTTYH1 splice variant that lacks the C-terminal glutamate-rich domain of hTTYH1 (hTTYH1sv) generated a swelling-activated Cl-current. I conclude that investigation of the tweety family will provide important information about large-conductance Cl- channel molecules."xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.org/dc/terms/identifier | "doi:10.1113/expphysiol.2005.031773"xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.org/dc/terms/identifier | "doi:10.1113/expphysiol.2005.031773"xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/name | "Exp. Physiol."xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/name | "Exp. Physiol."xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/pages | "141-147"xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/pages | "141-147"xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/title | "The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels."xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/title | "The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels."xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://purl.uniprot.org/core/volume | "91"xsd:string |
| http://purl.uniprot.org/citations/16219661 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16219661 |
| http://purl.uniprot.org/citations/16219661 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16219661 |
| http://purl.uniprot.org/citations/16219661 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16219661 |
| http://purl.uniprot.org/citations/16219661 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16219661 |
| http://purl.uniprot.org/uniprot/Q9W5A5 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16219661 |
| http://purl.uniprot.org/uniprot/Q9C0H2#attribution-D4CD4D6B41752DFAA515985B2B841EBB | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16219661 |
| http://purl.uniprot.org/uniprot/Q9W5A5#attribution-1C5EBBF40058B58ED41F5EEF173FDC1A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16219661 |
| http://purl.uniprot.org/uniprot/Q9W5A5#attribution-573D45E2E719E3AE925C7C4A417892A4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16219661 |