| http://purl.uniprot.org/citations/16219662 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16219662 | http://www.w3.org/2000/01/rdf-schema#comment | "Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is a minor HDL-associated protein. Because many minor HDL-associated proteins exchange between different lipoprotein classes during the postprandial state and are also involved in triglyceride (TG) metabolism, we hypothesized that GPI-PLD may play a role in the metabolism of TG-rich lipoproteins. To test this hypothesis, we examined the distribution of GPI-PLD among lipoprotein classes during a fat tolerance test in C57BL/6 and LDL receptor-deficient (LDLR(-/-)) mice fed either a chow or high-fructose diet. In the fasting state in wild-type mice fed a chow diet, GPI-PLD was only present in HDL, whereas in LDLR(-/-) mice GPI-PLD was present in HDL and intermediate-density lipoproteins (IDL)/LDL. During the fat tolerance test, there was no change in total serum GPI-PLD levels in either model; however, a significant amount of GPI-PLD appeared in both VLDL (0.5-1% of total GPI-PLD) and IDL/LDL (5-10% of total GPI-PLD) in both models. The high-fructose diet increased both fasting and postprandial TG and serum GPI-PLD levels in both strains as well as the amount of GPI-PLD in VLDL. To determine whether GPI-PLD plays a direct role in TG metabolism, we increased liver GPI-PLD expression in C57BL/6 mice by adenovirus-mediated gene transfer, which resulted in a sevenfold increase in serum GPI-PLD levels. This change was associated with an increase in fasting (30%) and postprandial TG (50%) and a twofold reduction in TG-rich lipoprotein catabolism compared with saline or control adenovirus-treated mice. These studies demonstrate that GPI-PLD affects serum TG levels by altering catabolism of TG-rich lipoproteins."xsd:string |
| http://purl.uniprot.org/citations/16219662 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpendo.00593.2004"xsd:string |
| http://purl.uniprot.org/citations/16219662 | http://purl.uniprot.org/core/author | "Cho W.K."xsd:string |
| http://purl.uniprot.org/citations/16219662 | http://purl.uniprot.org/core/author | "Deeg M.A."xsd:string |
| http://purl.uniprot.org/citations/16219662 | http://purl.uniprot.org/core/author | "Raikwar N.S."xsd:string |
| http://purl.uniprot.org/citations/16219662 | http://purl.uniprot.org/core/author | "Bowen R.F."xsd:string |
| http://purl.uniprot.org/citations/16219662 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16219662 | http://purl.uniprot.org/core/name | "Am J Physiol Endocrinol Metab"xsd:string |
| http://purl.uniprot.org/citations/16219662 | http://purl.uniprot.org/core/pages | "E463-70"xsd:string |
| http://purl.uniprot.org/citations/16219662 | http://purl.uniprot.org/core/title | "Glycosylphosphatidylinositol-specific phospholipase D influences triglyceride-rich lipoprotein metabolism."xsd:string |
| http://purl.uniprot.org/citations/16219662 | http://purl.uniprot.org/core/volume | "290"xsd:string |
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