| http://purl.uniprot.org/citations/16219795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16219795 | http://www.w3.org/2000/01/rdf-schema#comment | "Interleukin-12 (IL-12) is a heterodimeric cytokine produced by dendritic cells (DCs) in response to Toll-like receptor (TLR) ligation. While the mechanisms regulating IL-12p40 chain gene expression are well characterized, molecular events involved in IL-12p35 chain gene activation remain to be clarified. Since IL-12p35 mRNA was induced in human DCs activated through TLR3 or TLR4 but not TLR2, we investigated the potential role of interferon regulatory factor 3 (IRF-3) in IL-12p35 gene transactivation. First, a binding site for IRF-3 named interferon-stimulated response element-1 (ISRE-1) was identified in the human IL-12p35 promoter region between nucleotides -251 and -240. The ISRE-1 site was required for IL-12p35 gene activation in RAW 264.7 cells stimulated by lipopolysaccharide (LPS) or PolyI:C. Ectopic expression of IRF-3 was found to up-regulate IL-12p35 gene activation in the same system. Furthermore, chromatin immunoprecipitation (ChIP) studies demonstrated that IRF-3 is recruited to ISRE-1 site in TLR4- or TLR3-stimulated human DCs. Finally, experiments on DCs from IRF-3-deficient mice established that TLR4-induced IL-12p35 mRNA and IL-12p70 synthesis are impaired in absence of IRF-3. We conclude that IRF-3 binds to a critical cis-acting element in the IL-12p35 gene promoter and thereby represents a key factor for the induction of IL-12p70 synthesis in DCs."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2005-06-2416"xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/author | "Lin R."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/author | "Nguyen M."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/author | "Goriely S."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/author | "Willems F."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/author | "Goldman M."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/author | "De Wit D."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/author | "Flamand V."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/author | "Molle C."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/author | "Albarani V."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/author | "Haddou N.O."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/pages | "1078-1084"xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/title | "Interferon regulatory factor 3 is involved in Toll-like receptor 4 (TLR4)- and TLR3-induced IL-12p35 gene activation."xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/16219795 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16219795 |
| http://purl.uniprot.org/citations/16219795 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16219795 |
| http://purl.uniprot.org/uniprot/#_P70671-mappedCitation-16219795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16219795 |
| http://purl.uniprot.org/uniprot/#_A0A140LHE6-mappedCitation-16219795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16219795 |
| http://purl.uniprot.org/uniprot/#_A0A140LI96-mappedCitation-16219795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16219795 |
| http://purl.uniprot.org/uniprot/#_A0A140LJD9-mappedCitation-16219795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16219795 |
| http://purl.uniprot.org/uniprot/#_A0A140LJE8-mappedCitation-16219795 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16219795 |