| http://purl.uniprot.org/citations/16222715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16222715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16222715 | http://www.w3.org/2000/01/rdf-schema#comment | "Gene knockout studies of Krüppel-like factors (KLFs) in mice have shown essential roles in organogenesis. A screen for KLF family members in zebrafish identified many KLFs. One of these, zebrafish KLF4 (zKLF4) is the homologue of neptune, a Xenopus laevis KLF. zKLF4 is expressed from approximately 80% epiboly a patch of dorsal/anterior mesendodermal cells called the pre-polster and, subsequently, in the polster and hatching gland. Here we investigate the function of zKLF4 using morpholino-based antisense oligonucleotides. Knockdown of zKLF4 resulted in complete absence of hatching gland formation and subsequent hatching in zebrafish. In addition, there was early knockdown of expression of the pre-polster/anterior mesendoderm markers CatL, cap1, and BMP4. These results indicate zKLF4 is expressed within the pre-polster, an early mesendodermal site, and that it plays a critical role in the differentiation of these cells into hatching gland cells."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.20571"xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/author | "Zon L.I."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/author | "Zon L.I."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/author | "Gardiner M.R."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/author | "Gardiner M.R."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/author | "Perkins A.C."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/author | "Perkins A.C."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/author | "Daggett D.F."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/author | "Daggett D.F."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/name | "Dev. Dyn."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/name | "Dev Dyn"xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/pages | "992-996"xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/pages | "992-996"xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/title | "Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/title | "Zebrafish KLF4 is essential for anterior mesendoderm/pre-polster differentiation and hatching."xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/volume | "234"xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://purl.uniprot.org/core/volume | "234"xsd:string |
| http://purl.uniprot.org/citations/16222715 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16222715 |
| http://purl.uniprot.org/citations/16222715 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16222715 |
| http://purl.uniprot.org/citations/16222715 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16222715 |