| http://purl.uniprot.org/citations/16224817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16224817 | http://www.w3.org/2000/01/rdf-schema#comment | "HLA-E-restricted T cells represent a minor cytolytic T lymphocyte (CTL) population characterized by the surface expression of HLA class I-specific inhibitory receptors and by the capability of killing a large panel of allogeneic target cells (therefore named NK-CTL). Here we show that this subset of T cells is present in a sizeable fraction in the peripheral blood of human cytomegalovirus (HCMV)-seropositive healthy individuals. We provide evidence that NK-CTL recognize in an HLA-E-restricted fashion a naturally processed CMV-derived peptide in the transporter associated with antigen processing (TAP)-2(-/-) UL40+ RMA-S cell transfectants. Moreover, we show that they recognize and kill HCMV-infected target cells. NK-CTL are characterized by the CD8beta(dull) (CD45RA+)(CD28-)(CD27-)(CCR7-)(CD56+) surface phenotype, thus suggesting that they belong to the effector-memory cell compartment. Consistent with the effector-memory phenotype, they promptly produce IFN-gamma, but not IL-2, upon interaction with the specific HCMV UL40-derived peptide. Our data suggest that HLA-E-restricted CTL may represent an additional effector cell type involved in defenses against HCMV, a virus which escapes the control exerted by conventional CTL or NK cells."xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200535343"xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/author | "Coulie P."xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/author | "Falco M."xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/author | "Moretta L."xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/author | "Pietra G."xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/author | "Mingari M.C."xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/author | "Vacca P."xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/author | "Colau D."xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/author | "Mazzarino P."xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/pages | "3240-3247"xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/title | "Identification of effector-memory CMV-specific T lymphocytes that kill CMV-infected target cells in an HLA-E-restricted fashion."xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/16224817 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16224817 |
| http://purl.uniprot.org/citations/16224817 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16224817 |
| http://purl.uniprot.org/uniprot/#_A0A0F7WBW2-mappedCitation-16224817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16224817 |
| http://purl.uniprot.org/uniprot/#_A0A0A8LFF7-mappedCitation-16224817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16224817 |
| http://purl.uniprot.org/uniprot/#_A0A0F7W1Q1-mappedCitation-16224817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16224817 |
| http://purl.uniprot.org/uniprot/#_P13747-mappedCitation-16224817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16224817 |
| http://purl.uniprot.org/uniprot/#_A0A7L7TM74-mappedCitation-16224817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16224817 |
| http://purl.uniprot.org/uniprot/#_A0A4E9DQ67-mappedCitation-16224817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16224817 |
| http://purl.uniprot.org/uniprot/#_A0A4E9E4P1-mappedCitation-16224817 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16224817 |