http://purl.uniprot.org/citations/16225776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/16225776 | http://www.w3.org/2000/01/rdf-schema#comment | "Autoimmune mechanisms are likely involved in the pathogenesis of idiopathic dilated cardiomyopathy (IDC) and components of MHC may serve as markers for the propensity to develop immune-mediated myocardial damage. This study was conducted to investigate the possible association between HLA-DQA1, -DQB1 alleles and IDC in Han population from northern China by using PCR-based sequence-specific primer (PCR-SSP) technique for HLA genotyping. Among 68 unrelated IDC patients, 4 probands of IDC pedigrees and 100 healthy controls, we found that the alleles of HLA-DQA1*0501 and HLA-DQB1*0303 conferred susceptibility to IDC while HLA-DQA1*0201 and HLA-DQB1*0502, *0504 alleles were in negative association with IDC. The serine at position 57 (SER57) in the exon of HLA-DQB1*0502 and *0504 was confirmed in our experiment as a marker for resistance to IDC. The results suggest that HLA-DQ polymorphism may be involved in the pathogenesis of IDC."xsd:string |
http://purl.uniprot.org/citations/16225776 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
http://purl.uniprot.org/citations/16225776 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
http://purl.uniprot.org/citations/16225776 | http://purl.uniprot.org/core/author | "Sun N."xsd:string |
http://purl.uniprot.org/citations/16225776 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
http://purl.uniprot.org/citations/16225776 | http://purl.uniprot.org/core/name | "Cell Mol Immunol"xsd:string |
http://purl.uniprot.org/citations/16225776 | http://purl.uniprot.org/core/pages | "311-314"xsd:string |
http://purl.uniprot.org/citations/16225776 | http://purl.uniprot.org/core/title | "Association of HLA-DQ with idiopathic dilated cardiomyopathy in a northern Chinese Han population."xsd:string |
http://purl.uniprot.org/citations/16225776 | http://purl.uniprot.org/core/volume | "1"xsd:string |
http://purl.uniprot.org/citations/16225776 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16225776 |
http://purl.uniprot.org/citations/16225776 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16225776 |
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