| http://purl.uniprot.org/citations/16226721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16226721 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16226721 | http://www.w3.org/2000/01/rdf-schema#comment | "The SLC6 gene family comprises membrane proteins that transport neurotransmitters, amino acids, or osmolytes. We report the first functional characterization of the human SLC6A15 gene, which codes for a sodium-coupled branched-chain amino-acid transporter 1 (SBAT1). SBAT1 expression is specific to the brain. When expressed in Xenopus oocytes, SBAT1 mediated Na+-coupled transport of hydrophobic, zwitterionic alpha-amino and imino acids. SBAT1 exhibited a strong preference for branched-chain amino acids (BCAA) and methionine (K0.5 80-160 microM). SBAT1 excluded aromatic or charged amino acids, beta-amino acids, glycine, and GABA. SBAT1-mediated transport of amino or imino acids was extremely temperature-dependent (Q10=9) and was inhibited at acidic pH. PKC activation reduced the plasma-membrane population of SBAT1 protein. SBAT1-mediated transport of BCAA, particularly leucine, may be an important source of amino nitrogen for neurotransmitter synthesis in glutamatergic and GABAergic neurons."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.09.128"xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.09.128"xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/author | "Mackenzie B."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/author | "Mackenzie B."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/author | "Hediger M.A."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/author | "Hediger M.A."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/author | "Peng J.B."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/author | "Peng J.B."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/author | "Takanaga H."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/author | "Takanaga H."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/pages | "892-900"xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/pages | "892-900"xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/title | "Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/title | "Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain."xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/volume | "337"xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://purl.uniprot.org/core/volume | "337"xsd:string |
| http://purl.uniprot.org/citations/16226721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16226721 |
| http://purl.uniprot.org/citations/16226721 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16226721 |