| http://purl.uniprot.org/citations/16227264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16227264 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16227264 | http://www.w3.org/2000/01/rdf-schema#comment | "The V protein of simian virus 5 (SV5) facilitates the ubiquitination and subsequent proteasome-mediated degradation of STAT1. Here we show, by visualizing direct protein-protein interactions and by using the yeast two-hybrid system, that while the SV5 V protein fails to bind to STAT1 directly, it binds directly and independently to both DDB1 and STAT2, two cellular proteins known to be essential for SV5-mediated degradation of STAT1. We also demonstrate that STAT1 and STAT2 interact independently of SV5 V and show that SV5 V protein acts as an adaptor molecule linking DDB1 to STAT2/STAT1 heterodimers, which in the presence of additional accessory cellular proteins, including Cullin 4a, can ubiquitinate STAT1. Additionally, we show that the avidity of STAT2 for V is relatively weak but is significantly enhanced by the presence of both STAT1 and DDB1, i.e., the complex of STAT1, STAT2, DDB1, and SV5 V is more stable than a complex of STAT2 and V. From these studies we propose a dynamic model in which SV5 V acts as a bridge, bringing together a DDB1/Cullin 4a-containing ubiquitin ligase complex and STAT1/STAT2 heterodimers, which leads to the degradation of STAT1. The loss of STAT1 results in a decrease in affinity of binding of STAT2 for V such that STAT2 either dissociates from V or is displaced from V by STAT1/STAT2 complexes, thereby ensuring the cycling of the DDB1 and SV5 V containing E3 complex for continued rounds of STAT1 ubiquitination and degradation."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.21.13434-13441.2005"xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.21.13434-13441.2005"xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/author | "Precious B."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/author | "Precious B."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/author | "Childs K."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/author | "Childs K."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/author | "Goodbourn S."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/author | "Goodbourn S."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/author | "Randall R.E."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/author | "Randall R.E."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/author | "Fitzpatrick-Swallow V."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/author | "Fitzpatrick-Swallow V."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/pages | "13434-13441"xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/pages | "13434-13441"xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/title | "Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/title | "Simian virus 5 V protein acts as an adaptor, linking DDB1 to STAT2, to facilitate the ubiquitination of STAT1."xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/16227264 | http://purl.uniprot.org/core/volume | "79"xsd:string |