| http://purl.uniprot.org/citations/16227282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16227282 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16227282 | http://www.w3.org/2000/01/rdf-schema#comment | "Latency-associated nuclear antigen 1 (LANA-1) of Kaposi's sarcoma-associated herpesvirus (KSHV) mediates the episomal replication of the KSHV genome, as well as transcriptional regulation, in latently infected cells. Interaction of LANA-1 with cellular chromatin is required for both these functions. An N-terminal heterochromatin-binding site in LANA-1 is essential for the replication and maintenance of latent episomes, as well as transcriptional regulation. We have recently described a C-terminal domain in LANA-1 that modulates the interaction with cellular interphase chromatin or elements of the nuclear matrix. Here, we used a series of LANA-1 deletion mutants to investigate the relationship between the different functions of LANA-1 and its interaction with the host chromatin-binding protein Brd2/RING3. Our findings suggest that the C-terminal chromatin-binding domain in LANA-1 is required for multiple LANA-1 functions, including the ability to bind to and replicate viral episomal DNA, to modulate transcription, and to interact with Brd2/RING3. Similar to the recently described tethering of bovine papillomavirus E2 protein to host chromatin via Brd4/MCAP, Brd2/RING3, another member of the Brd family of chromatin-binding proteins, therefore interacts with a chromatin-binding region of another viral latent nuclear protein and could play a role in its multiple functions."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.21.13618-13629.2005"xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.21.13618-13629.2005"xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Schulz T.F."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Schulz T.F."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Koenig R."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Koenig R."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Bruening E."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Bruening E."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Buerger A."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Buerger A."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Kati E."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Kati E."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Ottinger M."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Ottinger M."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Sheldon J.A."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Sheldon J.A."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Viejo-Borbolla A."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/author | "Viejo-Borbolla A."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |
| http://purl.uniprot.org/citations/16227282 | http://purl.uniprot.org/core/name | "J. Virol."xsd:string |