| http://purl.uniprot.org/citations/16227293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16227293 | http://www.w3.org/2000/01/rdf-schema#comment | "Human immunodeficiency virus type 1 viral protein R (Vpr) is required for viral pathogenesis and has been implicated in T-cell apoptosis through its activation of caspase 3 and caspase 9 and perturbation of mitochondrial membrane potential. To understand better Vpr-mitochondria interaction, we report here the identification of antiapoptotic mitochondrial protein HAX-1 as a novel Vpr target. We show that Vpr and HAX-1 physically associate with each other. Overexpression of Vpr in cells dislocates HAX-1 from its normal residence in mitochondria and creates mitochondrion instability and cell death. Conversely, overexpression of HAX-1 suppressed the proapoptotic activity of Vpr."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.79.21.13735-13746.2005"xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/author | "Chen M.Y."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/author | "Dayton A.I."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/author | "Shih H.M."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/author | "Chang L.Y."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/author | "Lu C.Y."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/author | "Yedavalli V.S."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/author | "Jeang K.T."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/author | "Huang L.M."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/author | "Chuang C.Y."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/author | "Chiang Y.P."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/pages | "13735-13746"xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/title | "Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1."xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://purl.uniprot.org/core/volume | "79"xsd:string |
| http://purl.uniprot.org/citations/16227293 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16227293 |
| http://purl.uniprot.org/citations/16227293 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16227293 |
| http://purl.uniprot.org/uniprot/#_O00165-mappedCitation-16227293 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16227293 |
| http://purl.uniprot.org/uniprot/O00165 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16227293 |