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http://purl.uniprot.org/citations/16234315http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16234315http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16234315http://www.w3.org/2000/01/rdf-schema#comment"

Motivation

Coordinate regulation of gene expression can provide information on gene function. To begin a large-scale analysis of Dictyostelium gene function, we clustered genes based on their expression in wild-type and mutant strains and analyzed their functions.

Results

We found 17 modes of wild-type gene expression and refined them into 57 submodes considering mutant data. Annotation analyses revealed correlations between co-expression and function and an unexpected correlation between expression and function of genes involved in various aspects of chemotaxis. Co-regulation of chemotaxis genes was also found in published data from neutrophils. To test the predictive power of the analysis, we examined the phenotypes of mutations in seven co-regulated genes that had no published role in chemotaxis. Six mutants exhibited chemotaxis defects, supporting the idea that function can be inferred from co-expression. The clustering and annotation analyses provide a public resource for Dictyostelium functional genomics."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.org/dc/terms/identifier"doi:10.1093/bioinformatics/bti726"xsd:string
http://purl.uniprot.org/citations/16234315http://purl.org/dc/terms/identifier"doi:10.1093/bioinformatics/bti726"xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/author"Kuspa A."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/author"Kuspa A."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/author"Shaulsky G."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/author"Shaulsky G."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/author"Van Driessche N."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/author"Van Driessche N."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/author"Booth E.O."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/author"Booth E.O."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/author"Zhuchenko O."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/author"Zhuchenko O."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/name"Bioinformatics"xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/name"Bioinformatics"xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/pages"4371-4377"xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/pages"4371-4377"xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/title"Microarray phenotyping in Dictyostelium reveals a regulon of chemotaxis genes."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/title"Microarray phenotyping in Dictyostelium reveals a regulon of chemotaxis genes."xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/volume"21"xsd:string
http://purl.uniprot.org/citations/16234315http://purl.uniprot.org/core/volume"21"xsd:string
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