| http://purl.uniprot.org/citations/16236125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16236125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16236125 | http://www.w3.org/2000/01/rdf-schema#comment | "It has been previously shown that the subset of human natural killer (NK) cells which express CD8 in a homodimeric alpha/alpha form are more cytotoxic than their CD8-counterparts but the mechanisms behind this differential cytolytic activity remained unknown. Target cell lysis by CD8-NK cells is associated with high levels of effector cell apoptosis, which is in contrast to the significantly lower levels found in the CD8alpha+ cells after lysis of the same targets. We report that cross-linking of the CD8alpha chains on NK cells induces rapid rises in intracellular Ca2+ and increased expression of CD69 at the cell surface by initiating the influx of extracellular Ca2+ ions. We demonstrate that secretion of cytolytic enzymes initiates NK-cell apoptosis from which CD8alpha+ NK cells are protected by an influx of exogenous calcium following ligation of CD8 on the NK-cell surface. This ligation is through interaction with fellow NK cells in the cell conjugate and can occur when the target cells lack major histocompatibility complex (MHC) Class I expression. Protection from apoptosis is blocked by preincubation of the NK cells with anti-MHC Class I antibody. Thus, in contrast to the CD8-subset, CD8alpha+ NK cells are capable of sequential lysis of multiple target cells."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2567.2005.02235.x"xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2567.2005.02235.x"xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Davies J.K."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Davies J.K."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Al-Sarraj S."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Al-Sarraj S."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Addison E.G."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Addison E.G."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Bakhsh I."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Bakhsh I."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Haq S."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Haq S."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Lowdell M.W."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Lowdell M.W."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Malayeri R."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Malayeri R."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Marden C."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Marden C."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "North J."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "North J."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Wickremasinghe R.G."xsd:string |
| http://purl.uniprot.org/citations/16236125 | http://purl.uniprot.org/core/author | "Wickremasinghe R.G."xsd:string |