| http://purl.uniprot.org/citations/16236763 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16236763 | http://www.w3.org/2000/01/rdf-schema#comment | "Homologous recombination (HR) is a mechanism for repairing DNA interstrand crosslinks and double-strand breaks. In mammals, HR requires the activities of the RAD51 family (RAD51, RAD51B, RAD51C, RAD51D, XRCC2, XRCC3 and DMC1), each of which contains conserved ATP binding sequences (Walker Motifs A and B). RAD51D is a DNA-stimulated ATPase that interacts directly with RAD51C and XRCC2. To test the hypothesis that ATP binding and hydrolysis by RAD51D are required for the repair of interstrand crosslinks, site-directed mutations in Walker Motif A were generated, and complementation studies were performed in Rad51d-deficient mouse embryonic fibroblasts. The K113R and K113A mutants demonstrated a respective 96 and 83% decrease in repair capacity relative to wild-type. Further examination of these mutants, by yeast two-hybrid analyses, revealed an 8-fold reduction in the ability to associate with RAD51C whereas interaction with XRCC2 was retained at a level similar to the S111T control. These cell-based studies are the first evidence that ATP binding and hydrolysis by RAD51D are required for efficient HR repair of DNA interstrand crosslinks."xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.org/dc/terms/identifier | "doi:10.1093/mutage/gei059"xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/author | "Balder R."xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/author | "Miller K.A."xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/author | "Pittman D.L."xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/author | "Albala J.S."xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/author | "Smiraldo P.G."xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/author | "Rajesh C."xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/author | "Gruver A.M."xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/author | "Kaliyaperumal S."xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/author | "Stiles K.M."xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/name | "Mutagenesis"xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/pages | "433-440"xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/title | "The ATPase motif in RAD51D is required for resistance to DNA interstrand crosslinking agents and interaction with RAD51C."xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/16236763 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16236763 |
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