| http://purl.uniprot.org/citations/16236769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16236769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16236769 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel mode of crosstalk between the EGFR-Ras-MAPK and LIN-12/Notch pathways occurs during the patterning of a row of vulval precursor cells (VPCs) in Caenorhabditis elegans: activation of the EGFR-Ras-MAPK pathway in the central VPC promotes endocytosis and degradation of LIN-12 protein. LIN-12 downregulation in the central VPC is a prerequisite for the activity of the lateral signal, which activates LIN-12 in neighboring VPCs. Here we characterize cis-acting targeting sequences in the LIN-12 intracellular domain and find that in addition to a di-leucine motif, serine/threonine residues are important for internalization and lysine residues are important for post-internalization trafficking and degradation. We also identify two trans-acting factors that are required for post-internalization trafficking and degradation: ALX-1, a homolog of yeast Bro1p and mammalian Alix and the WWP-1/Su(dx)/Itch ubiquitin ligase. By examining the effects of mutated forms of LIN-12 and reduced wwp-1 or alx-1 activity on subcellular localization and activity of LIN-12, we provide evidence that the lateral signal-inhibiting activity of LIN-12 resides in the extracellular domain and occurs at the apical surface of the VPCs."xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.02076"xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.02076"xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/author | "Greenwald I."xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/author | "Greenwald I."xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/author | "Shaye D.D."xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/author | "Shaye D.D."xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/pages | "5081-5092"xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/pages | "5081-5092"xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/title | "LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/title | "LIN-12/Notch trafficking and regulation of DSL ligand activity during vulval induction in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/volume | "132"xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://purl.uniprot.org/core/volume | "132"xsd:string |
| http://purl.uniprot.org/citations/16236769 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16236769 |
| http://purl.uniprot.org/citations/16236769 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16236769 |
| http://purl.uniprot.org/citations/16236769 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16236769 |
| http://purl.uniprot.org/citations/16236769 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16236769 |
| http://purl.uniprot.org/uniprot/P34552 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16236769 |
| http://purl.uniprot.org/uniprot/P34552#attribution-46E6C7B4E140921939ACE6CF641E3D7C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16236769 |