| http://purl.uniprot.org/citations/16237069 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16237069 | http://www.w3.org/2000/01/rdf-schema#comment | "Although fully MHC-mismatched murine cardiac allografts are rapidly rejected, allografts mismatched at only MHC class I or class II alleles survive long term; the immunologic basis for the long-term survival of MHC class I- or II-mismatched allografts is unknown. We examined the roles of two recently described inhibitory receptors, B and T lymphocyte attenuator (BTLA) and programmed death-1 (PD-1), in the survival of partially or fully MHC-mismatched allografts using gene-deficient recipients as well as through use of blocking mAbs in wild-type hosts. Partially MHC-mismatched allografts showed strong induction of BTLA, but not PD-1 mRNA and survived long term in wild-type recipients, whereas targeting of BTLA or its ligand, herpesvirus entry mediator, but not PD-1, prompted their rapid rejection. By contrast, fully MHC-mismatched cardiac allografts were acutely rejected in wild-type recipients despite the induction of both BTLA and PD-1. Targeting of PD-1 in several fully MHC-mismatched models accelerated rejection, whereas targeting of BTLA unexpectedly enhanced PD-1 induction by alloreactive CD4 and CD8 T cells and prolonged allograft survival. In vitro studies using allogeneic dendritic cells and T cells showed that at low levels of T cell activation, BTLA expression was primarily induced, but that with increasing degrees of T cell activation, the expression of PD-1 was strongly up-regulated. These data suggest that BTLA and PD-1 exert distinct inhibitory actions in vivo, with the BTLA/herpesvirus entry mediator pathway appearing to dominate in regulating responses against a restricted degree of allogeneic mismatch."xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.175.9.5774"xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/author | "Wang T."xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/author | "Ye Q."xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/author | "Honjo T."xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/author | "Han R."xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/author | "Tao R."xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/author | "Murphy K.M."xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/author | "Murphy T.L."xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/author | "Hancock W.W."xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/pages | "5774-5782"xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/title | "Differential effects of B and T lymphocyte attenuator and programmed death-1 on acceptance of partially versus fully MHC-mismatched cardiac allografts."xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://purl.uniprot.org/core/volume | "175"xsd:string |
| http://purl.uniprot.org/citations/16237069 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16237069 |
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