| http://purl.uniprot.org/citations/16239149 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16239149 | http://www.w3.org/2000/01/rdf-schema#comment | "Phagocytosis is a complex, evolutionarily conserved process that plays a central role in host defense against infection. We have identified a predicted transmembrane protein, Eater, which is involved in phagocytosis in Drosophila. Transcriptional silencing of the eater gene in a macrophage cell line led to a significant reduction in the binding and internalization of bacteria. Moreover, the N terminus of the Eater protein mediated direct microbial binding which could be inhibited with scavenger receptor ligands, acetylated, and oxidized low-density lipoprotein. In vivo, eater expression was restricted to blood cells. Flies lacking the eater gene displayed normal responses in NF-kappaB-like Toll and IMD signaling pathways but showed impaired phagocytosis and decreased survival after bacterial infection. Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.08.034"xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Meister M."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Kocks C."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Cho J.H."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Stehle T."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Hetru C."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Hoffmann J.A."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Reichhart J.M."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Ulvila J."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Stuart L.M."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Ramet M."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Ezekowitz R.A."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Nehme N."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Ferrandon D."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Strom C."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Pearson A.M."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/author | "Conto S.L."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/pages | "335-346"xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/title | "Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/16239149 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16239149 |