| http://purl.uniprot.org/citations/16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16239929 | http://www.w3.org/2000/01/rdf-schema#comment | "We have characterised the apoptotic defects in cells null for cytochrome c (cyt c-/-). Such cells treated with staurosporine (STS) exhibited translocation to the mitochondria and activation of the proapoptotic signalling molecule Bax but failed to release Smac/DIABLO from these organelles, judged by both confocal microscopy and Western blotting. While reference cells expressing cytochrome c released both it and Smac/DIABLO under a variety of conditions of apoptotic induction, we have never observed release of Smac/DIABLO from cyt c-/-cells. We eliminate the possibility that proteasomal degradation of cytosolically localised Smac/DIABLO is responsible for our failure to visualise the protein outside the mitochondria. Our findings indicate an unanticipated nexus between release of cytochrome c and Smac/DIABLO from mitochondria, previously thought to be a more or less synchronised event early in apoptosis. We suggest that the failure of cyt c-/-cells to release Smac/DIABLO after recruitment of Bax to mitochondria represents an extreme manifestation of some inherent difference in the regulation of release of these two proteins from mitochondria."xsd:string |
| http://purl.uniprot.org/citations/16239929 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.cdd.4401795"xsd:string |
| http://purl.uniprot.org/citations/16239929 | http://purl.uniprot.org/core/author | "Smith D.J."xsd:string |
| http://purl.uniprot.org/citations/16239929 | http://purl.uniprot.org/core/author | "Nagley P."xsd:string |
| http://purl.uniprot.org/citations/16239929 | http://purl.uniprot.org/core/author | "Hansen T.M."xsd:string |
| http://purl.uniprot.org/citations/16239929 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16239929 | http://purl.uniprot.org/core/name | "Cell Death Differ"xsd:string |
| http://purl.uniprot.org/citations/16239929 | http://purl.uniprot.org/core/pages | "1181-1190"xsd:string |
| http://purl.uniprot.org/citations/16239929 | http://purl.uniprot.org/core/title | "Smac/DIABLO is not released from mitochondria during apoptotic signalling in cells deficient in cytochrome c."xsd:string |
| http://purl.uniprot.org/citations/16239929 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/16239929 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16239929 |
| http://purl.uniprot.org/citations/16239929 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16239929 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGS0-mappedCitation-16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16239929 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VHK1-mappedCitation-16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16239929 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VI32-mappedCitation-16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16239929 |
| http://purl.uniprot.org/uniprot/#_A0A2R8VK14-mappedCitation-16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16239929 |
| http://purl.uniprot.org/uniprot/#_D3Z2Q3-mappedCitation-16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16239929 |
| http://purl.uniprot.org/uniprot/#_D3Z3K5-mappedCitation-16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16239929 |
| http://purl.uniprot.org/uniprot/#_Q3TEL3-mappedCitation-16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16239929 |
| http://purl.uniprot.org/uniprot/#_Q7TPS3-mappedCitation-16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16239929 |
| http://purl.uniprot.org/uniprot/#_Q9JIQ3-mappedCitation-16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16239929 |
| http://purl.uniprot.org/uniprot/#_Q8R1D8-mappedCitation-16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16239929 |
| http://purl.uniprot.org/uniprot/#_Q9D0M3-mappedCitation-16239929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16239929 |
| http://purl.uniprot.org/uniprot/A0A2R8VK14 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16239929 |