| http://purl.uniprot.org/citations/16242150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16242150 | http://www.w3.org/2000/01/rdf-schema#comment | "The p66shc adaptor protein mediates age-associated oxidative stress. We examined the role of p66shc in endothelial nitric oxide synthase (eNOS) signaling. Overexpression of p66shc inhibited eNOS-dependent NO production. RNAi-mediated down-regulation of endogenous p66shc led to activation of the proto-oncogene ras, and Akt kinase, with a corresponding increase in phosphorylation of eNOS at S1177 (S1179 on bovine eNOS). In rat aortic rings, down-regulation of p66shc suppressed the vasoconstrictor response to phenyephrine that was abrogated by treatment with the NOS inhibitor l-NAME, and enhanced vasodilation induced by sub-maximal doses of acetylcholine. These findings highlight a pivotal role for p66shc in inhibiting endothelial NO production, and endothelium-dependent vasorelaxation, that may provide important mechanistic information about endothelial dysfunction seen with aging."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yjmcc.2005.09.003"xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/author | "White A.R."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/author | "Haile A."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/author | "Qi B."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/author | "Irani K."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/author | "Kasuno K."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/author | "Mattagajasingh I."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/author | "Yamamori T."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/author | "Berkowitz D.E."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/author | "Khanday F.A."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/author | "Bugayenko A."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/author | "Jeon B.H."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/name | "J Mol Cell Cardiol"xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/pages | "992-995"xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/title | "P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction."xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/16242150 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16242150 |
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| http://purl.uniprot.org/uniprot/#_Q5M824-mappedCitation-16242150 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16242150 |