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| http://purl.uniprot.org/citations/16242404 | http://www.w3.org/2000/01/rdf-schema#comment | "Previous studies suggested that postsynaptic neuroligins form a trans-synaptic complex with presynaptic beta-neurexins, but not with presynaptic alpha-neurexins. Unexpectedly, we now find that neuroligins also bind alpha-neurexins and that alpha- and beta-neurexin binding by neuroligin 1 is regulated by alternative splicing of neuroligin 1 (at splice site B) and of neurexins (at splice site 4). In neuroligin 1, splice site B is a master switch that determines alpha-neurexin binding but leaves beta-neurexin binding largely unaffected, whereas alternative splicing of neurexins modulates neuroligin binding. Moreover, neuroligin 1 splice variants with distinct neurexin binding properties differentially regulate synaptogenesis: neuroligin 1 that binds only beta-neurexins potently stimulates synapse formation, whereas neuroligin 1 that binds to both alpha- and beta-neurexins more effectively promotes synapse expansion. These findings suggest that neuroligin binding to alpha- and beta-neurexins mediates trans-synaptic cell adhesion but has distinct effects on synapse formation, indicating that expression of different neuroligin and neurexin isoforms specifies a trans-synaptic signaling code."xsd:string |
| http://purl.uniprot.org/citations/16242404 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2005.08.026"xsd:string |
| http://purl.uniprot.org/citations/16242404 | http://purl.uniprot.org/core/author | "Taylor P."xsd:string |
| http://purl.uniprot.org/citations/16242404 | http://purl.uniprot.org/core/author | "Boucard A.A."xsd:string |
| http://purl.uniprot.org/citations/16242404 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/16242404 | http://purl.uniprot.org/core/author | "Comoletti D."xsd:string |
| http://purl.uniprot.org/citations/16242404 | http://purl.uniprot.org/core/author | "Chubykin A.A."xsd:string |
| http://purl.uniprot.org/citations/16242404 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16242404 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/16242404 | http://purl.uniprot.org/core/pages | "229-236"xsd:string |
| http://purl.uniprot.org/citations/16242404 | http://purl.uniprot.org/core/title | "A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins."xsd:string |
| http://purl.uniprot.org/citations/16242404 | http://purl.uniprot.org/core/volume | "48"xsd:string |
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