| http://purl.uniprot.org/citations/16245071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16245071 | http://www.w3.org/2000/01/rdf-schema#comment | "Acid sphingomyelinase (A-SMase) and its reaction product ceramide may play a role in the pathophysiology of depressive disorders and in the therapeutic action of antidepressive drugs. In a prospective case-control study, A-SMase activity was measured in peripheral blood mononuclear cells of 17 patients with a major depressive episode who were free of antidepressant drug therapy for at least 10 days and 8 healthy volunteers. In the patient group, A-SMase activity was correlated to the score (n=17, r=0.64, P=0.005). The patient group exhibited higher A-SMase activity compared to healthy volunteers (T=2.09, df=21.33, P<0.05). In addition, we demonstrate that the antidepressants imipramine and amitriptyline induce a long-term reduction of the activity of A-SMase in cultured cells."xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00702-005-0374-5"xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/author | "Henkel A.W."xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/author | "Gulbins E."xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/author | "Kornhuber J."xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/author | "Jendrossek V."xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/author | "Wiltfang J."xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/author | "Bleich S."xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/author | "Medlin A."xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/name | "J Neural Transm (Vienna)"xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/pages | "1583-1590"xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/title | "High activity of acid sphingomyelinase in major depression."xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://purl.uniprot.org/core/volume | "112"xsd:string |
| http://purl.uniprot.org/citations/16245071 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16245071 |
| http://purl.uniprot.org/citations/16245071 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16245071 |
| http://purl.uniprot.org/uniprot/#_Q15496-mappedCitation-16245071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16245071 |
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| http://purl.uniprot.org/uniprot/#_P17405-mappedCitation-16245071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16245071 |
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