| http://purl.uniprot.org/citations/16245339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16245339 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16245339 | http://www.w3.org/2000/01/rdf-schema#comment | "We have cloned the chicken and mouse orthologues of the Caenorhabditis elegans heterochronic gene lin-41. During limb development, lin-41 is expressed in three phases over developmental time and most notably is associated with the developing autopod. Using chicken and mouse mutants and bead implantations, we report that lin-41 is genetically and biochemically downstream of both the Shh and Fgf signaling pathways. In C. elegans, it is proposed that lin-41 activity is temporally regulated by miRNAs (let-7 and lin-4) that bind to complementary sites in the lin-41 3'-untranslated region (UTR). Taking a bioinformatics approach, we also report the presence of potential miRNA binding sites in the 3'-UTR of chicken lin-41, including sites for the chicken orthologues of both C. elegans let-7 and lin-4. Finally, we show that these miRNAs and others are expressed in the chick limb consistent with the hypothesis that they regulate chicken Lin-41 activity in vivo."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.20591"xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.20591"xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Pertsemlidis A."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Pertsemlidis A."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Pasquinelli A.E."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Pasquinelli A.E."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Harfe B.D."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Harfe B.D."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Fallon J.F."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Fallon J.F."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Caruccio N.C."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Caruccio N.C."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Lancman J.J."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Lancman J.J."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Schageman J.J."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/author | "Schageman J.J."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/name | "Dev. Dyn."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/name | "Dev. Dyn."xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/pages | "948-960"xsd:string |
| http://purl.uniprot.org/citations/16245339 | http://purl.uniprot.org/core/pages | "948-960"xsd:string |