| http://purl.uniprot.org/citations/16246306 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16246306 | http://www.w3.org/2000/01/rdf-schema#comment | "Prostaglandin F(2alpha) (PGF(2alpha)) is a vasoactive factor that causes constriction and hypertrophy of vascular smooth muscle cells (VSMCs). However, the mechanism of PGF(2alpha)-induced hypertrophy is largely unknown. Cyclic AMP-response element (CRE)-binding protein (CREB), the best characterized stimulus-induced transcription factor, activates transcription of target genes with CRE and promotes cell growth. We examined the role of CREB in PGF(2alpha)-induced hypertrophy of VSMCs. PGF(2alpha) induced phosphorylation of CREB at serine 133, which is a critical marker of activation, after 5-10min of stimulation in a dose-dependent manner. Pharmacological inhibition of extracellular signal-regulated protein kinase and p38 mitogen-activated protein kinase (p38-MAPK) suppressed PGF(2alpha)-induced CREB phosphorylation. Inhibition of epidermal growth factor receptor (EGFR) and mitogen- and stress-activated protein kinase-1 also suppressed PGF(2alpha)-induced CREB phosphorylation. Overexpression of dominant-negative form of CREB (AdCREB M1), of which serine 133 was replaced with alanine, inhibited PGF(2alpha)-induced c-fos mRNA expression as well as hypertrophy of VSMCs [hypertrophy index (microg/10(4)cell); control 8.13, PGF(2alpha) 9.85, AdCREB M1 7.91, and AdCREB M1+PGF(2alpha) 8.43]. These results suggest that PGF(2alpha) activated CRE-dependent gene transcription through EGFR transactivation, and the CREB pathway plays a critical role in PGF(2alpha)-induced hypertrophy of VSMCs."xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2005.10.019"xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/author | "Fukuyama K."xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/author | "Masuda S."xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/author | "Ono H."xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/author | "Takeshita A."xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/author | "Iino N."xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/author | "Ichiki T."xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/author | "Ohtsubo H."xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/author | "Tokunou T."xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/pages | "910-918"xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/title | "cAMP-response element-binding protein mediates prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells."xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://purl.uniprot.org/core/volume | "338"xsd:string |
| http://purl.uniprot.org/citations/16246306 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16246306 |
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