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http://purl.uniprot.org/citations/16250632http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16250632http://www.w3.org/2000/01/rdf-schema#comment"Design, synthesis, and biological evaluation of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease (SARS-3CLpro) inhibitors for severe acute respiratory syndrome coronavirus (SARS-CoV) are described. These inhibitors exhibited antiviral activity against SARS-CoV in infected cells in the micromolar range. An X-ray crystal structure of our lead inhibitor (4) bound to SARS-3CLpro provided important drug-design templates for the design of small-molecule inhibitors."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.org/dc/terms/identifier"doi:10.1021/jm050548m"xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/author"Rota P.A."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/author"Ghosh A.K."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/author"Baker S.C."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/author"Fu W."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/author"Harcourt B.H."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/author"Santarsiero B.D."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/author"Mesecar A.D."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/author"Ratia K."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/author"Johnson M.E."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/author"Xi K."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/name"J Med Chem"xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/pages"6767-6771"xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/title"Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors."xsd:string
http://purl.uniprot.org/citations/16250632http://purl.uniprot.org/core/volume"48"xsd:string
http://purl.uniprot.org/citations/16250632http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16250632
http://purl.uniprot.org/citations/16250632http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16250632
http://purl.uniprot.org/uniprot/#_P0C6U8-mappedCitation-16250632http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16250632
http://purl.uniprot.org/uniprot/#_P0C6X7-mappedCitation-16250632http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16250632
http://purl.uniprot.org/uniprot/P0C6U8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16250632
http://purl.uniprot.org/uniprot/P0C6X7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16250632