| http://purl.uniprot.org/citations/16251435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16251435 | http://www.w3.org/2000/01/rdf-schema#comment | "Current knowledge about the molecular mechanisms of NMDA receptor (NMDAR)-independent long-term potentiation (LTP) in the hippocampus and its function for memory formation in the behaving animal is limited. NMDAR-independent LTP in the CA1 region is thought to require activity of postsynaptic L-type voltage-dependent Ca2+ channels (Cav1.x), but the underlying channel isoform remains unknown. We evaluated the function of the Cav1.2 L-type Ca2+ channel for spatial learning, synaptic plasticity, and triggering of learning-associated biochemical processes using a mouse line with an inactivation of the CACNA1C (Cav1.2) gene in the hippocampus and neocortex (Cav1.2(HCKO)). This model shows (1) a selective loss of protein synthesis-dependent NMDAR-independent Schaffer collateral/CA1 late-phase LTP (L-LTP), (2) a severe impairment of hippocampus-dependent spatial memory, and (3) decreased activation of the mitogen-activated protein kinase (MAPK) pathway and reduced cAMP response element (CRE)-dependent transcription in CA1 pyramidal neurons. Our results provide strong evidence for a role of L-type Ca2+ channel-dependent, NMDAR-independent hippocampal L-LTP in the formation of spatial memory in the behaving animal and for a function of the MAPK/CREB (CRE-binding protein) signaling cascade in linking Cav1.2 channel-mediated Ca2+ influx to either process."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.1531-05.2005"xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Klugbauer N."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Muller J."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Storm D.R."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Hofmann F."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Nave K.A."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Stiess M."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Moosmang S."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Schulla V."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Lacinova L."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Marais E."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Haider N."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Goebbels S."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Adelsberger H."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Kleppisch T."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/author | "Langwieser N."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/pages | "9883-9892"xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/title | "Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory."xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16251435 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16251435 |
| http://purl.uniprot.org/citations/16251435 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16251435 |