| http://purl.uniprot.org/citations/16253242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16253242 | http://www.w3.org/2000/01/rdf-schema#comment | "The co-signaling molecule B7-H1 (CD274) functions as both a co-inhibitor through programmed death-1 (PD-1) receptor and a co-stimulator via an as-yet-unidentified receptor on T cells. We investigated the physiological role of endogenous B7-H1 in the pathogenesis of herpetic stromal keratitis (HSK) caused by herpes simplex virus type 1 (HSV-1). Following HSV-1 infection of the cornea of mice, B7-H1 expression was up-regulated in the CD11b+ macrophage population in the draining lymph nodes (dLN) and in the inflamed cornea. In addition, HSV-1 infection significantly increased PD-1 expression on CD4+ T cells in the dLN and inflamed cornea. The administration of antagonistic B7-H1 monoclonal antibody resulted in the proliferation of HSV-specific CD4+ T cells that secreted interferon (INF)-gamma, and inhibited the apoptosis of HSV-specific CD4+ T cells, which exaggerated HSK. These results strongly suggest that the B7-H1 may be involved in suppression of the development of HSK."xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2005.09.098"xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/author | "Chen L."xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/author | "Zhu G."xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/author | "Choi I.H."xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/author | "Jeong H.Y."xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/author | "Seo S.K."xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/author | "Jun H."xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/author | "Seo H.M."xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/pages | "6259-6264"xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/title | "B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK)."xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://purl.uniprot.org/core/volume | "579"xsd:string |
| http://purl.uniprot.org/citations/16253242 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16253242 |
| http://purl.uniprot.org/citations/16253242 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16253242 |
| http://purl.uniprot.org/uniprot/#_Q3U472-mappedCitation-16253242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16253242 |
| http://purl.uniprot.org/uniprot/#_Q9EP73-mappedCitation-16253242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16253242 |
| http://purl.uniprot.org/uniprot/Q3U472 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16253242 |
| http://purl.uniprot.org/uniprot/Q9EP73 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16253242 |