| http://purl.uniprot.org/citations/16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16254053 | http://www.w3.org/2000/01/rdf-schema#comment | "Class II major histocompatibility (MHC-II) genes are prototype targets of IFN-gamma. IFN-gamma activates the expression of the non-DNA-binding master regulator of MHC-II, class II transactivator (CIITA), which is crucial for enhanceosome formation and gene activation. This report shows the importance of the histone methyltransferase, coactivator-associated arginine methyltransferase (CARM1/PRMT4), during IFN-gamma-induced MHC-II gene activation. It also demonstrates the coordinated regulation of CIITA, CARM1, and the acetyltransferase cyclic-AMP response element binding (CREB)-binding protein (CBP) during this process. CARM1 synergizes with CIITA in activating MHC-II transcription and synergy is abrogated when an arginine methyltransferase-defective CARM1 mutant is used. Protein-arginine methyltransferase 1 has much less effect on MHC-II transcription. Specific RNA interference reduced CARM1 expression as well as MHC-II expression. The recruitment of CARM1 to the promoter requires endogenous CIITA and results in methylation of histone H3-R17; hence, CIITA is an upstream regulator of histone methylation. Previous work has shown that CARM1 can methylate CBP at three arginine residues. Using wild-type CBP and a mutant of CBP lacking the CARM1-targeted arginine residues (R3A), we show that arginine methylation of CBP is required for IFN-gamma induction of MHC-II. A kinetic analysis shows that CIITA, CARM1, and H3-R17 methylation all precede CBP loading on the MHC-II promoter during IFN-gamma treatment. These results suggest functional and temporal relationships among CIITA, CARM1, and CBP for IFN-gamma induction of MHC-II."xsd:string |
| http://purl.uniprot.org/citations/16254053 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0505045102"xsd:string |
| http://purl.uniprot.org/citations/16254053 | http://purl.uniprot.org/core/author | "Ting J.P."xsd:string |
| http://purl.uniprot.org/citations/16254053 | http://purl.uniprot.org/core/author | "Vandel L."xsd:string |
| http://purl.uniprot.org/citations/16254053 | http://purl.uniprot.org/core/author | "Fauquier L."xsd:string |
| http://purl.uniprot.org/citations/16254053 | http://purl.uniprot.org/core/author | "Zika E."xsd:string |
| http://purl.uniprot.org/citations/16254053 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16254053 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16254053 | http://purl.uniprot.org/core/pages | "16321-16326"xsd:string |
| http://purl.uniprot.org/citations/16254053 | http://purl.uniprot.org/core/title | "Interplay among coactivator-associated arginine methyltransferase 1, CBP, and CIITA in IFN-gamma-inducible MHC-II gene expression."xsd:string |
| http://purl.uniprot.org/citations/16254053 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/16254053 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16254053 |
| http://purl.uniprot.org/citations/16254053 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16254053 |
| http://purl.uniprot.org/uniprot/#_A0A0B4J1S1-mappedCitation-16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16254053 |
| http://purl.uniprot.org/uniprot/#_A0A087X2I7-mappedCitation-16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16254053 |
| http://purl.uniprot.org/uniprot/#_B5A210-mappedCitation-16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16254053 |
| http://purl.uniprot.org/uniprot/#_B5A211-mappedCitation-16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16254053 |
| http://purl.uniprot.org/uniprot/#_B5A212-mappedCitation-16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16254053 |
| http://purl.uniprot.org/uniprot/#_B5A213-mappedCitation-16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16254053 |
| http://purl.uniprot.org/uniprot/#_B5A214-mappedCitation-16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16254053 |
| http://purl.uniprot.org/uniprot/#_B5A215-mappedCitation-16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16254053 |
| http://purl.uniprot.org/uniprot/#_B5A216-mappedCitation-16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16254053 |
| http://purl.uniprot.org/uniprot/#_B5A217-mappedCitation-16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16254053 |
| http://purl.uniprot.org/uniprot/#_B5A218-mappedCitation-16254053 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16254053 |