| http://purl.uniprot.org/citations/16257509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16257509 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent genetic evidence demonstrated that Shc is a critical molecule for T cell activation and differentiation. However, how Shc is coupled to the T cell antigen receptor (TCR) has not been clearly characterized. Here we report that the tyrosine kinase Lck functions as a connecting molecule for TCR and Shc. Lck plays a critical role in TCR signal transduction by phosphorylating the immuno-receptor tyrosine based activation motif (ITAM). Our data shows that the PTB domain of Shc binds the SH2/3 domains of Lck in a phosphotyrosine-independent manner. Inhibition of the Lck/Shc interaction led to the loss of IL-2 promoter activation, confirming that the role of Shc in IL-2 production requires its interaction with Lck. Together, the data show that Shc is connected to the activated TCR via direct interaction with Lck."xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2005.09.008"xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://purl.uniprot.org/core/author | "Singh N."xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://purl.uniprot.org/core/author | "Fukushima A."xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://purl.uniprot.org/core/author | "Hatanaka Y."xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://purl.uniprot.org/core/author | "Chang J.W."xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://purl.uniprot.org/core/author | "Iwashima M."xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://purl.uniprot.org/core/author | "Takamatsu M."xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16257509 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://purl.uniprot.org/core/pages | "1182-1189"xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://purl.uniprot.org/core/title | "Lck couples Shc to TCR signaling."xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://purl.uniprot.org/core/volume | "18"xsd:string |
| http://purl.uniprot.org/citations/16257509 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16257509 |
| http://purl.uniprot.org/citations/16257509 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16257509 |
| http://purl.uniprot.org/uniprot/#_E9PJ92-mappedCitation-16257509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16257509 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3T3-mappedCitation-16257509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16257509 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z3Y8-mappedCitation-16257509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16257509 |
| http://purl.uniprot.org/uniprot/#_B3KUV3-mappedCitation-16257509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16257509 |
| http://purl.uniprot.org/uniprot/#_B4DL02-mappedCitation-16257509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16257509 |
| http://purl.uniprot.org/uniprot/#_B4DZS7-mappedCitation-16257509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16257509 |
| http://purl.uniprot.org/uniprot/#_P06239-mappedCitation-16257509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16257509 |
| http://purl.uniprot.org/uniprot/#_Q573B4-mappedCitation-16257509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16257509 |
| http://purl.uniprot.org/uniprot/#_P29353-mappedCitation-16257509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16257509 |