| http://purl.uniprot.org/citations/16260621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16260621 | http://www.w3.org/2000/01/rdf-schema#comment | "p53 binding protein 1 (53BP1) is a putative DNA damage sensor that accumulates at sites of double-strand breaks (DSBs) in a manner dependent on histone H2AX. Here we show that the loss of one or both copies of 53BP1 greatly accelerates lymphomagenesis in a p53-null background, suggesting that 53BP1 and p53 cooperate in tumor suppression. A subset of 53BP1-/- p53-/-lymphomas, like those in H2AX-/- p53-/-mice, were diploid and harbored clonal translocations involving antigen receptor loci, indicating misrepair of DSBs during V(D)J recombination as one cause of oncogenic transformation. Loss of a single 53BP1 allele compromised genomic stability and DSB repair, which could explain the susceptibility of 53BP1+/-mice to tumorigenesis. In addition to structural aberrations, there were high rates of chromosomal missegregation and accumulation of aneuploid cells in 53BP1-/- p53+/+ and 53BP1-/- p53-/- tumors as well as in primary 53BP1-/-splenocytes. We conclude that 53BP1 functions as a dosage-dependent caretaker that promotes genomic stability by a mechanism that preserves chromosome structure and number."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.22.10079-10086.2005"xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/author | "Chen J."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/author | "Yu X."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/author | "Nussenzweig A."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/author | "Ried T."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/author | "Minn K."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/author | "Ward I.M."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/author | "Difilippantonio S."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/author | "Mueller M.D."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/author | "Molina J.R."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/author | "Frisk C.S."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/pages | "10079-10086"xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/title | "53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice."xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16260621 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16260621 |
| http://purl.uniprot.org/citations/16260621 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16260621 |
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| http://purl.uniprot.org/uniprot/#_A6YM30-mappedCitation-16260621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16260621 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-16260621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16260621 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-16260621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16260621 |
| http://purl.uniprot.org/uniprot/#_A5JTV6-mappedCitation-16260621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16260621 |