| http://purl.uniprot.org/citations/16262723 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16262723 | http://www.w3.org/2000/01/rdf-schema#comment | "The bidirectional nature of late endosome/lysosome movement suggests involvement of at least two distinct motors, one minus-end directed and one plus-end directed. Previous work has identified dynein as the minus-end-directed motor for late endosome/lysosome localization and dynamics. Conventional kinesin (kinesin-1) has been implicated in plus-end-directed late endosome/lysosome movement, but other kinesin family members may also be involved. Kinesin-2 is known to drive the movement of pigment granules, a type of lysosomally derived organelle, and was recently found to be associated with purified late endosomes. To determine whether kinesin-2 might also power endosome movement in non-pigmented cells, we overexpressed dominant negative forms of the KIF3A motor subunit and KAP3 accessory subunit and knocked down KAP3 levels using RNAi. We found kinesin-2 to be required for the normal steady-state localization of late endosomes/lysosomes but not early endosomes or recycling endosomes. Despite the abnormal subcellular distribution of late endosomes/lysosomes, the uptake and trafficking of molecules through the conventional endocytic pathway appeared to be unaffected. The slow time-course of inhibition suggests that both kinesin-2 itself and its attachment to membranes do not turn over quickly."xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-0854.2005.00347.x"xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/author | "Maier K.C."xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/author | "Schroer T.A."xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/author | "Vernos I."xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/author | "Stauber T."xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/author | "Wordeman L."xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/author | "Brown C.L."xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/author | "Ginkel L.M."xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/name | "Traffic"xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/pages | "1114-1124"xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/title | "Kinesin-2 is a motor for late endosomes and lysosomes."xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/16262723 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16262723 |
| http://purl.uniprot.org/citations/16262723 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16262723 |
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