RDF/XMLNTriplesTurtleShow queryShare
SubjectPredicateObject
http://purl.uniprot.org/citations/16263078http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16263078http://www.w3.org/2000/01/rdf-schema#comment"Infection of SARS-associated coronavirus (SARS-CoV) induced a strong anti-nucleocapsid (anti-N) antibody response. However, the pathophysiological significance of the anti-N antibodies in SARS pathogenesis is largely unknown. To profile the anti-N antibodies, a phage-displayed scFv library was prepared from mice immunized with heat-inactivated SARS-CoV-infected Vero E6 cell lysate. Specific anti-N scFvs were isolated by panning against a recombinant nucleocapsid protein and reactivity was confirmed with phage-ELISA. Sequence analysis indicated that two of the isolated anti-N scFv clones were identical and displayed a high homology with an scFv specific for interleukin 11 (IL-11), an anti-inflammatory cytokine derived from bone marrow stroma cells. In a neutralization assay, IL-11-induced STAT 3 phosphorylation in rat intestinal epithelial IEC-18 cells was completely suppressed by the anti-N scFv clone L9N01."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.org/dc/terms/identifier"doi:10.1016/j.bbrc.2005.10.088"xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/author"Lee S.S."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/author"Cheng M."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/author"Chan C.W."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/author"Chan P.K."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/author"Zhao Q."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/author"Au S.W."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/author"Cheng G."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/author"Cheung W.T."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/author"Bikkavilli R.K."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/author"Ho W.K."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/author"Cheung R.C."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/name"Biochem Biophys Res Commun"xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/pages"1654-1660"xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/title"Cross-reactivity of antibody against SARS-coronavirus nucleocapsid protein with IL-11."xsd:string
http://purl.uniprot.org/citations/16263078http://purl.uniprot.org/core/volume"338"xsd:string
http://purl.uniprot.org/citations/16263078http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16263078
http://purl.uniprot.org/citations/16263078http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16263078
http://purl.uniprot.org/uniprot/#_P52631-mappedCitation-16263078http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/16263078
http://purl.uniprot.org/uniprot/P52631http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/16263078