| http://purl.uniprot.org/citations/16267776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16267776 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundOn the basis of a polymerase chain reaction-restriction fragment-length polymorphism analysis of the 16S-23S ribosomal DNA intergenic spacer, clinical isolates of Borrelia burgdorferi can be classified into 3 genotypes designated as RST1, RST2, and RST3. RST1 strains are the most pathogenic, and RST3 strains are the least pathogenic.MethodsHuman leukocyte antigen (HLA) class II alleles were determined for a group of culture-positive patients with Lyme disease-associated erythema migrans and were evaluated for an association with the genotype of the infecting B. burgdorferi strain.ResultsThe DRB1*0101 allele carriage rate was higher in patients infected with RST3 strains (9/25 [36.0%]) than in patients infected with RST1 strains (2/28 [7.1%]) or RST2 strains (7/36 [19.4%]) (P=.010). The same relationship was found for carriage of the DRB1*0101-DQB1*0501 haplotype (P=.018), because of tight linkage disequilibrium. Similar associations could not be demonstrated for any of the other DRB1 and DQB1 alleles or haplotypes that were assessed.ConclusionThe DRB1*0101 allele and the DRB1*0101-DQB1*0501 haplotype may be relevant to the development of infection with strains from the least invasive genotypes of B. burgdorferi."xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.org/dc/terms/identifier | "doi:10.1086/497693"xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/author | "Schwartz I."xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/author | "Wade K."xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/author | "Kaslow R."xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/author | "Liveris D."xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/author | "Wormser G.P."xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/author | "Klempner M."xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/name | "J Infect Dis"xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/pages | "2020-2026"xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/title | "Association between human leukocyte antigen class II alleles and genotype of Borrelia burgdorferi in patients with early lyme disease."xsd:string |
| http://purl.uniprot.org/citations/16267776 | http://purl.uniprot.org/core/volume | "192"xsd:string |
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