| http://purl.uniprot.org/citations/16270627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16270627 | http://www.w3.org/2000/01/rdf-schema#comment | "The development of anti-factor VIII (FVIII) antibodies is currently one of the most serious complications in the treatment of haemophilia A patients. Numerous studies in literature report on their epitope specificity, their mechanism of FVIII inactivation, and their relationship with FVIII genetic alterations. During the last two years, however, a particular effort has been made to better understand their generation, with particular emphasis on the interplay of T cells and B cells specific for FVIII and the generation of anti-FVIII antibodies. Moreover, novel strategies to improve the management or treatment of patients with anti-FVIII antibodies have been recently proposed: the use of less immunogenic engineered recombinant FVIII molecules, neutralization of inhibitors by blocking their deleterious activity either by low molecular weight peptide decoys or by anti-idiotypic antibodies, and attempts to suppress the T-cell response involved in the antibody formation. All of these represent promising therapeutic approaches. This review attempts to sum up current knowledge of the nature and properties of anti-FVIII antibodies, their mechanism of action, their neutralization by anti-idiotypic antibodies, and the role of T cells in FVIII inhibitor formation. In the final part, some of the new strategies susceptible to improve the management or the eradication of anti-FVIII antibodies are presented."xsd:string |
| http://purl.uniprot.org/citations/16270627 | http://purl.org/dc/terms/identifier | "doi:10.1160/th05-02-0118"xsd:string |
| http://purl.uniprot.org/citations/16270627 | http://purl.uniprot.org/core/author | "Granier C."xsd:string |
| http://purl.uniprot.org/citations/16270627 | http://purl.uniprot.org/core/author | "Villard S."xsd:string |
| http://purl.uniprot.org/citations/16270627 | http://purl.uniprot.org/core/author | "Schved J.F."xsd:string |
| http://purl.uniprot.org/citations/16270627 | http://purl.uniprot.org/core/author | "Lavigne-Lissalde G."xsd:string |
| http://purl.uniprot.org/citations/16270627 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16270627 | http://purl.uniprot.org/core/name | "Thromb Haemost"xsd:string |
| http://purl.uniprot.org/citations/16270627 | http://purl.uniprot.org/core/pages | "760-769"xsd:string |
| http://purl.uniprot.org/citations/16270627 | http://purl.uniprot.org/core/title | "Anti-factor VIII antibodies: a 2005 update."xsd:string |
| http://purl.uniprot.org/citations/16270627 | http://purl.uniprot.org/core/volume | "94"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A1Y1BZT1-mappedCitation-16270627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16270627 |
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| http://purl.uniprot.org/uniprot/#_A0A127R644-mappedCitation-16270627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16270627 |
| http://purl.uniprot.org/uniprot/#_A0FJ19-mappedCitation-16270627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16270627 |