| http://purl.uniprot.org/citations/16272201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16272201 | http://www.w3.org/2000/01/rdf-schema#comment | "Both atrial (ANP) and brain (BNP) natriuretic peptide affect development of cardiac hypertrophy and fibrosis via binding to natriuretic peptide receptor (NPR)-A in the heart. A putative clearance receptor, NPR-C, is believed to regulate cardiac levels of ANP and BNP. The renin-angiotensin system also affects cardiac hypertrophy and fibrosis. In this study we examined the expression of genes for the NPRs in rats with pressure-overload cardiac hypertrophy. The ANG II type 1 receptor was blocked with losartan (10 mg.kg(-1).day(-1)) to investigate a possible role of the renin-angiotensin system in regulation of natriuretic peptide and NPR gene expression. The ascending aorta was banded in 84 rats during Hypnorm/Dormicum-isoflurane anesthesia; after 4 wk the rats were randomized to treatment with losartan or placebo. The left ventricle of the heart was removed 1, 2, or 4 wk later. Aortic banding increased left ventricular expression of NPR-A and NPR-C mRNA by 110% (P < 0.001) and 520% (P < 0.01), respectively, after 8 wk; as expected, it also increased the expression of ANP and BNP mRNAs. Losartan induced a slight reduction of left ventricular weight but did not affect the expression of mRNAs for the natriuretic peptides or their receptors. Although increased gene expression does not necessarily convey a higher concentration of the protein, the data suggest that pressure overload is accompanied by upregulation of not only ANP and BNP but also their receptors NPR-A and NPR-C in the left ventricle."xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.00612.2005"xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/author | "Busk P.K."xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/author | "Nielsen L.B."xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/author | "Sheikh S.P."xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/author | "Haunso S."xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/author | "Skott O."xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/author | "Aplin M."xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/author | "Christoffersen T.E."xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/author | "Strom C.C."xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/name | "Am J Physiol Heart Circ Physiol"xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/pages | "H1635-41"xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/title | "Increased natriuretic peptide receptor A and C gene expression in rats with pressure-overload cardiac hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://purl.uniprot.org/core/volume | "290"xsd:string |
| http://purl.uniprot.org/citations/16272201 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16272201 |
| http://purl.uniprot.org/citations/16272201 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16272201 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZSQ4-mappedCitation-16272201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16272201 |
| http://purl.uniprot.org/uniprot/#_A0A8I6AIA6-mappedCitation-16272201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16272201 |
| http://purl.uniprot.org/uniprot/#_A0A8I5Y501-mappedCitation-16272201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16272201 |
| http://purl.uniprot.org/uniprot/#_B0BMW5-mappedCitation-16272201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16272201 |
| http://purl.uniprot.org/uniprot/#_P13205-mappedCitation-16272201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16272201 |
| http://purl.uniprot.org/uniprot/#_P18910-mappedCitation-16272201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16272201 |
| http://purl.uniprot.org/uniprot/#_P01161-mappedCitation-16272201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16272201 |