| http://purl.uniprot.org/citations/16275912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16275912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16275912 | http://www.w3.org/2000/01/rdf-schema#comment | "Resistance to inhibitors of cholinesterase (Ric) 8A is a guanine nucleotide exchange factor that activates certain G protein alpha-subunits. Genetic studies in Caenorhabditis elegans and Drosophila melanogaster have placed RIC-8 in a previously uncharacterized G protein signaling pathway that regulates centrosome movements during cell division. Components of this pathway include G protein subunits of the Galphai class, GPR or GoLoco domain-containing proteins, RGS (regulator of G protein signaling) proteins, and accessory factors. These proteins interact to regulate microtubule pulling forces during mitotic movement of chromosomes. It is unclear how the GTP-binding and hydrolysis cycle of Galphai functions in the context of this pathway. In mammals, the GoLoco domain-containing protein LGN (GPSM2), the LGN- and microtubule-binding nuclear mitotic apparatus protein (NuMA), and Galphai regulate a similar process. We find that mammalian Ric-8A dissociates Galphai-GDP/LGN/NuMA complexes catalytically, releasing activated Galphai-GTP in vitro. Ric-8A-stimulated activation of Galphai caused concomitant liberation of NuMA from LGN. We conclude that Ric-8A efficiently utilizes GoLoco/Galphai-GDP complexes as substrates in vitro and suggest that Ric-8A-stimulated release of Galphai-GTP and/or NuMA regulates the microtubule pulling forces on centrosomes during cell division."xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0508306102"xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0508306102"xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/author | "Gilman A.G."xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/author | "Gilman A.G."xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/author | "Tall G.G."xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/author | "Tall G.G."xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/pages | "16584-16589"xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/pages | "16584-16589"xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/title | "Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes."xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/title | "Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes."xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/16275912 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16275912 |
| http://purl.uniprot.org/citations/16275912 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16275912 |
| http://purl.uniprot.org/citations/16275912 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16275912 |
| http://purl.uniprot.org/citations/16275912 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16275912 |
| http://purl.uniprot.org/uniprot/Q80ZG1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/16275912 |
| http://purl.uniprot.org/uniprot/Q80ZG1#attribution-1ADA3B0526C6978A6418FC15A871D1A2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16275912 |