| http://purl.uniprot.org/citations/16277691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16277691 | http://www.w3.org/2000/01/rdf-schema#comment | "The objective of this study was to examine HLA-DRB1 and HLA-DQB1 genotypes in patients with severe extra-articular rheumatoid arthritis (ExRA) and to compare them with the genotypes of rheumatoid arthritis (RA) patients without extra-articular manifestations. Patients with severe ExRA were recruited from a large research database of patients with RA, from two cohorts of prevalent RA cases, and from a regional multicenter early RA cohort. Cases with ExRA manifestations (n = 159) were classified according to predefined criteria. Controls (n = 178) with RA but no ExRA were selected from the same sources. Cases and controls were matched for duration of RA and for clinical center. PCR based HLA-DRB1 and HLA-DQB1 genotyping was performed using the Biotest SSP kit, with additional sequencing in order to distinguish DRB1*04 subtypes. Associations between alleles and disease phenotypes were tested using multiple simulations of random distributions of alleles. There was no difference in global distribution of HLA-DRB1 and HLA-DQB1 alleles between patients with ExRA and controls. DRB1*0401 (P = 0.003) and 0401/0401 homozygosity (P = 0.002) were more frequent in Felty's syndrome than in controls. The presence of two HLA-DRB1*04 alleles encoding the shared epitope (SE) was associated with ExRA (overall odds ratio 1.79, 95% confidence interval 1.04-3.08) and with rheumatoid vasculitis (odds ratio 2.44, 95% confidence interval 1.22-4.89). In this large sample of patients with ExRA, Felty's syndrome was the only manifestation that was clearly associated with HLA-DRB1*0401. Other ExRA manifestations were not associated with individual alleles but with DRB1*04 SE double dose genotypes. This confirms that SE genes contribute to RA disease severity and ExRA. Other genetic and environmental factors may have a more specific impact on individual ExRA manifestations."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.org/dc/terms/identifier | "doi:10.1186/ar1837"xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/author | "Schaid D.J."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/author | "Sturfelt G."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/author | "Truedsson L."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/author | "Goronzy J.J."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/author | "Weyand C.M."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/author | "Dechant S.A."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/author | "Jacobsson L.T."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/author | "Matteson E.L."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/author | "Nyhall-Wahlin B.M."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/author | "Petersson I.F."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/author | "Turesson C."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/name | "Arthritis Res Ther"xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/pages | "R1386-93"xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/title | "The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis."xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/16277691 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16277691 |
| http://purl.uniprot.org/citations/16277691 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16277691 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-16277691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16277691 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-16277691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16277691 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C3I5-mappedCitation-16277691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16277691 |
| http://purl.uniprot.org/uniprot/#_A0A0E3DC97-mappedCitation-16277691 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16277691 |