| http://purl.uniprot.org/citations/16280379 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16280379 | http://www.w3.org/2000/01/rdf-schema#comment | "Cadmium (Cd2+) is known to cause a selective disruption of the filamentous actin cytoskeleton in the smooth muscle-like renal mesangial cell. We examined the effect of Cd2+ on the distribution of the actin-severing protein, gelsolin. Over 8 h, CdCl2 (10 microM) caused a progressive shift of gelsolin from a diffuse perinuclear and cytoplasmic distribution to a pattern decorating F-actin filaments. Over this time filaments were decreased in number in many cells, and membrane ruffling was initiated. Western blotting and 125I-F-actin gel overlays demonstrated an increase in actin-binding gelsolin activity in the cytoskeletal fraction of cell extracts following Cd2+ treatment. In in vitro polymerization assays, gelsolin acted as a nucleating factor and increased the rate of polymerization. Cytosolic extracts also increased the polymerization rate. Addition of Cd2+ together with gelsolin further increased the rate of polymerization. Gelsolin enhanced depolymerization of purified actin, and Cd2+ partially suppressed this effect. However, cytoskeletal extracts from Cd2+-treated cells also markedly increased depolymerization, suggesting further that Cd2+ may activate cellular component(s) such as gelsolin for actin binding. We conclude that a major effect of Cd2+ on the mesangial cell cytoskeleton is manifest through activating the association of gelsolin with actin, with gelsolin's severing properties predominating under conditions found in Cd2+-treated cells."xsd:string |
| http://purl.uniprot.org/citations/16280379 | http://purl.org/dc/terms/identifier | "doi:10.1093/toxsci/kfj035"xsd:string |
| http://purl.uniprot.org/citations/16280379 | http://purl.uniprot.org/core/author | "Templeton D.M."xsd:string |
| http://purl.uniprot.org/citations/16280379 | http://purl.uniprot.org/core/author | "Apostolova M.D."xsd:string |
| http://purl.uniprot.org/citations/16280379 | http://purl.uniprot.org/core/author | "Christova T."xsd:string |
| http://purl.uniprot.org/citations/16280379 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16280379 | http://purl.uniprot.org/core/name | "Toxicol Sci"xsd:string |
| http://purl.uniprot.org/citations/16280379 | http://purl.uniprot.org/core/pages | "465-474"xsd:string |
| http://purl.uniprot.org/citations/16280379 | http://purl.uniprot.org/core/title | "Involvement of gelsolin in cadmium-induced disruption of the mesangial cell cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/16280379 | http://purl.uniprot.org/core/volume | "89"xsd:string |
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