| http://purl.uniprot.org/citations/16282976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16282976 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16282976 | http://www.w3.org/2000/01/rdf-schema#comment | "Celiac disease is probably the best-understood immune-related disorder. The disease presents in the small intestine and results from the interplay between multiple genes and gluten, the triggering environmental factor. Although HLA class II genes explain 40% of the heritable risk, non-HLA genes accounting for most of the familial clustering have not yet been identified. Here we report significant and replicable association (P = 2.1 x 10(-6)) to a common variant located in intron 28 of the gene myosin IXB (MYO9B), which encodes an unconventional myosin molecule that has a role in actin remodeling of epithelial enterocytes. Individuals homozygous with respect to the at-risk allele have a 2.3-times higher risk of celiac disease (P = 1.55 x 10(-5)). This result is suggestive of a primary impairment of the intestinal barrier in the etiology of celiac disease, which may explain why immunogenic gluten peptides are able to pass through the epithelial barrier."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1680"xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng1680"xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Daly M.J."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Daly M.J."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Wijmenga C."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Wijmenga C."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Zhernakova A."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Zhernakova A."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Franke L."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Franke L."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Strengman E."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Strengman E."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "van Belzen M.J."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "van Belzen M.J."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Mearin M.L."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Mearin M.L."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Mulder C.J."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Mulder C.J."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Wapenaar M.C."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "Wapenaar M.C."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "de Bakker P.I."xsd:string |
| http://purl.uniprot.org/citations/16282976 | http://purl.uniprot.org/core/author | "de Bakker P.I."xsd:string |