| http://purl.uniprot.org/citations/16284118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16284118 | http://www.w3.org/2000/01/rdf-schema#comment | "While testing the functions of deletion mutants in the Hox protein Ultrabithorax (Ubx), we found that the embryonic repression function of Ubx on Distal-less transcription in limb primordia is highly concentration dependent. The steep sigmoidal relationship between in vivo Ubx concentration and Distal-less repression is dependent on the Ubx YPWM motif. This suggests that Ubx cooperatively assembles a multi-protein repression complex on Distal-less regulatory DNA with the YPWM motif as a key protein-protein interface in this complex. Our deletion mutants also provide evidence for a transcriptional activation domain in the N-terminal 19 amino acids of Ubx. This proposed activation domain contains a variant of the SSYF motif that is found at the N termini of many Hox proteins, and is conserved in the activation domain of another Hox protein, Sex combs reduced. These results suggest that the N-terminal region containing the SSYF motif has been conserved in many Hox proteins for its role in transcriptional activation."xsd:string |
| http://purl.uniprot.org/citations/16284118 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.02138"xsd:string |
| http://purl.uniprot.org/citations/16284118 | http://purl.uniprot.org/core/author | "McGinnis W."xsd:string |
| http://purl.uniprot.org/citations/16284118 | http://purl.uniprot.org/core/author | "Hittinger C.T."xsd:string |
| http://purl.uniprot.org/citations/16284118 | http://purl.uniprot.org/core/author | "Tour E."xsd:string |
| http://purl.uniprot.org/citations/16284118 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16284118 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/16284118 | http://purl.uniprot.org/core/pages | "5271-5281"xsd:string |
| http://purl.uniprot.org/citations/16284118 | http://purl.uniprot.org/core/title | "Evolutionarily conserved domains required for activation and repression functions of the Drosophila Hox protein Ultrabithorax."xsd:string |
| http://purl.uniprot.org/citations/16284118 | http://purl.uniprot.org/core/volume | "132"xsd:string |
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