| http://purl.uniprot.org/citations/16284392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16284392 | http://www.w3.org/2000/01/rdf-schema#comment | "The presence of the PvuII or the XbaI polymorphism in the estrogen receptor alpha gene (ESR1, 6q25) has been related to breast cancer risk; however, results are not fully consistent. To further elucidate this relation, we examined these polymorphisms in relation with mammographic density, a measure of dense tissue in the breast, which is strongly associated with breast cancer risk. For this study, 620 participants aged 49 to 68 years were selected from the Prospect-European Prospective Investigation into Cancer and Nutrition cohort. Blood samples, lifestyle- and medical questionnaire data and mammograms were available for these women. Genotyping was done using the TaqMan PCR assay and mammographic density was assessed using a computer-assisted method. Means of mammographic density were compared by ESR1 genotypes and haplotypes. The percentage density was higher in women with one or two copies of the PvuII p allele (means for Pp and pp are 37% and 36%, respectively) than in those with the PP genotype (32%, P(trend) = 0.09). Women with one or two copies of the XbaI x allele had higher mean percentage density (Xx and xx, 36% and 37%, respectively) than those with the XX genotype (31%, P(trend) < 0.01). Haplotype 1 (px) was associated with increased density, whereas haplotype 2 (PX) was associated with decreased density, both suggesting an allele-dose effect (P(trend) = 0.08 and <0.01, respectively). Similar associations were found with absolute density (P(trend) < 0.01). The findings of this study support the view that ESR1 polymorphisms may affect breast cancer risk through differences in breast density."xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.org/dc/terms/identifier | "doi:10.1158/1055-9965.epi-05-0398"xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/author | "Uitterlinden A.G."xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/author | "Grobbee D.E."xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/author | "Roest M."xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/author | "van Gils C.H."xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/author | "Peeters P.H."xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/author | "van Duijnhoven F.J."xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/author | "Bezemer I.D."xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/name | "Cancer Epidemiol Biomarkers Prev"xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/pages | "2655-2660"xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/title | "Polymorphisms in the estrogen receptor alpha gene and mammographic density."xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://purl.uniprot.org/core/volume | "14"xsd:string |
| http://purl.uniprot.org/citations/16284392 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16284392 |
| http://purl.uniprot.org/citations/16284392 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16284392 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW0-mappedCitation-16284392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16284392 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW1-mappedCitation-16284392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16284392 |
| http://purl.uniprot.org/uniprot/#_Q14268-mappedCitation-16284392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16284392 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV8-mappedCitation-16284392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16284392 |
| http://purl.uniprot.org/uniprot/#_A0A125SXV9-mappedCitation-16284392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16284392 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW2-mappedCitation-16284392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16284392 |
| http://purl.uniprot.org/uniprot/#_A0A125SXW3-mappedCitation-16284392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16284392 |
| http://purl.uniprot.org/uniprot/#_B6DU68-mappedCitation-16284392 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16284392 |